DYNLRB1 explained

Dynein light chain roadblock-type 1 is a protein that in humans is encoded by the DYNLRB1 gene.^{[1] [2] [3]}

This gene is a member of the roadblock dynein light chain family and encodes a cytoplasmic protein that is capable of binding intermediate chain proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression.

Further reading

• Zhang QH, Ye M, Wu XY . Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells . Genome Res. . 10 . 10 . 1546–60 . 2001 . 11042152 . 10.1101/gr.140200 . 310934 . etal.
• Deloukas P, Matthews LH, Ashurst J . The DNA sequence and comparative analysis of human chromosome 20 . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . 2001Natur.414..865D . etal. free .
• Susalka SJ, Nikulina K, Salata MW . The roadblock light chain binds a novel region of the cytoplasmic Dynein intermediate chain . J. Biol. Chem. . 277 . 36 . 32939–46 . 2002 . 12077152 . 10.1074/jbc.M205510200 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Huang YS, Carson JH, Barbarese E, Richter JD . Facilitation of dendritic mRNA transport by CPEB . Genes Dev. . 17 . 5 . 638–53 . 2003 . 12629046 . 10.1101/gad.1053003 . 196011 .
• Gevaert K, Goethals M, Martens L . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides . Nat. Biotechnol. . 21 . 5 . 566–9 . 2004 . 12665801 . 10.1038/nbt810 . 23783563 . etal.
• Saito Y, Doi K, Yamagishi N . Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems . Biochem. Biophys. Res. Commun. . 314 . 2 . 396–402 . 2004 . 14733918 . 10.1016/j.bbrc.2003.12.108 . etal.
• Lehner B, Sanderson CM . A Protein Interaction Framework for Human mRNA Degradation . Genome Res. . 14 . 7 . 1315–23 . 2004 . 15231747 . 10.1101/gr.2122004 . 442147 .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Campbell IG, Phillips WA, Choong DY . Genetic and epigenetic analysis of the putative tumor suppressor km23 in primary ovarian, breast, and colorectal cancers . Clin. Cancer Res. . 12 . 12 . 3713–5 . 2006 . 16778097 . 10.1158/1078-0432.CCR-06-0800 . 24551435 .
• Pérez-González A, Rodriguez A, Huarte M . hCLE/CGI-99, a human protein that interacts with the influenza virus polymerase, is a mRNA transcription modulator . J. Mol. Biol. . 362 . 5 . 887–900 . 2007 . 16950395 . 10.1016/j.jmb.2006.07.085 . etal.
• Liu JF, Wang ZX, Wang XQ . Crystal structure of human dynein light chain Dnlc2A: structural insights into the interaction with IC74 . Biochem. Biophys. Res. Commun. . 349 . 3 . 1125–9 . 2006 . 16970917 . 10.1016/j.bbrc.2006.08.161 . etal.
• Kang HC, Kim IJ, Kim K . km23, a transforming growth factor-beta signaling component, is infrequently mutated in human colorectal and gastric cancers . Cancer Genet. Cytogenet. . 175 . 2 . 173–4 . 2007 . 17556076 . 10.1016/j.cancergencyto.2007.02.004 . etal.
• Wanschers B, van de Vorstenbosch R, Fransen J . Rab6 family proteins interact with the dynein light chain protein DYNLRB1 . Cell Motil. Cytoskeleton . 65 . 3 . 183–96 . 2008 . 18044744 . 10.1002/cm.20254. etal.

Notes and References

1. Jiang J, Yu L, Huang X, Chen X, Li D, Zhang Y, Tang L, Zhao S . Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients . Gene . 281 . 1–2 . 103–13 . Dec 2001 . 11750132 . 10.1016/S0378-1119(01)00787-9 .
2. Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB . Cytoplasmic dynein nomenclature . J Cell Biol . 171 . 3 . 411–3 . Nov 2005 . 16260502 . 2171247 . 10.1083/jcb.200508078 .
3. Web site: Entrez Gene: DYNLRB1 dynein, light chain, roadblock-type 1.