DYNLL2 explained

Dynein light chain 2, cytoplasmic is a protein that in humans is encoded by the DYNLL2 gene.^{[1] [2]}

Interactions

DYNLL2 has been shown to interact with DLG4,^[3] C12orf40,^[4] DLGAP1,^[3] MYO5A^{[3] [5]} and BMF.^{[5] [6]}

Further reading

• Naisbitt S, Valtschanoff J, Allison DW, Sala C, Kim E, Craig AM, Weinberg RJ, Sheng M . Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein . The Journal of Neuroscience . 20 . 12 . 4524–4534 . June 2000 . 10844022 . 6772433 . 10.1523/JNEUROSCI.20-12-04524.2000 . free .
• Haraguchi K, Satoh K, Yanai H, Hamada F, Kawabuchi M, Akiyama T . The hDLG-associated protein DAP interacts with dynein light chain and neuronal nitric oxide synthase . Genes to Cells . 5 . 11 . 905–911 . November 2000 . 11122378 . 10.1046/j.1365-2443.2000.00374.x . 37107139 . free .
• Puthalakath H, Villunger A, O'Reilly LA, Beaumont JG, Coultas L, Cheney RE, Huang DC, Strasser A . Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis . Science . 293 . 5536 . 1829–1832 . September 2001 . 11546872 . 10.1126/science.1062257 . 5638023 . 2001Sci...293.1829P .
• Fuhrmann JC, Kins S, Rostaing P, El Far O, Kirsch J, Sheng M, Triller A, Betz H, Kneussel M . Gephyrin interacts with Dynein light chains 1 and 2, components of motor protein complexes . The Journal of Neuroscience . 22 . 13 . 5393–5402 . July 2002 . 12097491 . 6758200 . 10.1523/JNEUROSCI.22-13-05393.2002 . free .
• Day CL, Puthalakath H, Skea G, Strasser A, Barsukov I, Lian LY, Huang DC, Hinds MG . Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands . The Biochemical Journal . 377 . Pt 3 . 597–605 . February 2004 . 14561217 . 1223895 . 10.1042/BJ20031251 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–1178 . October 2005 . 16189514 . 10.1038/nature04209 . 4427026 . 2005Natur.437.1173R .

Further reading

• Donner J, Pirkola S, Silander K, Kananen L, Terwilliger JD, Lönnqvist J, Peltonen L, Hovatta I . An association analysis of murine anxiety genes in humans implicates novel candidate genes for anxiety disorders . Biological Psychiatry . 64 . 8 . 672–680 . October 2008 . 18639233 . 2682432 . 10.1016/j.biopsych.2008.06.002 .

Notes and References

1. Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB . Cytoplasmic dynein nomenclature . The Journal of Cell Biology . 171 . 3 . 411–413 . November 2005 . 16260502 . 2171247 . 10.1083/jcb.200508078 .
2. Web site: Entrez Gene: DYNLL2 dynein, light chain, LC8-type 2.
3. Naisbitt S, Valtschanoff J, Allison DW, Sala C, Kim E, Craig AM, Weinberg RJ, Sheng M . Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein . The Journal of Neuroscience . 20 . 12 . 4524–4534 . June 2000 . 10844022 . 6772433 . 10.1523/JNEUROSCI.20-12-04524.2000 . free .
4. Rolland T, Taşan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, Yi S, Lemmens I, Fontanillo C, Mosca R, Kamburov A, Ghiassian SD, Yang X, Ghamsari L, Balcha D, Begg BE, Braun P, Brehme M, Broly MP, Carvunis AR, Convery-Zupan D, Corominas R, Coulombe-Huntington J, Dann E, Dreze M, Dricot A, Fan C, Franzosa E, Gebreab F, Gutierrez BJ, Hardy MF, Jin M, Kang S, Kiros R, Lin GN, Luck K, MacWilliams A, Menche J, Murray RR, Palagi A, Poulin MM, Rambout X, Rasla J, Reichert P, Romero V, Ruyssinck E, Sahalie JM, Scholz A, Shah AA, Sharma A, Shen Y, Spirohn K, Tam S, Tejeda AO, Wanamaker SA, Twizere JC, Vega K, Walsh J, Cusick ME, Xia Y, Barabási AL, Iakoucheva LM, Aloy P, De Las Rivas J, Tavernier J, Calderwood MA, Hill DE, Hao T, Roth FP, Vidal M . A proteome-scale map of the human interactome network . Cell . 159 . 5 . 1212–1226 . November 2014 . 25416956 . 4266588 . 10.1016/j.cell.2014.10.050 .
5. Puthalakath H, Villunger A, O'Reilly LA, Beaumont JG, Coultas L, Cheney RE, Huang DC, Strasser A . Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis . Science . 293 . 5536 . 1829–1832 . September 2001 . 11546872 . 10.1126/science.1062257 . 5638023 . 2001Sci...293.1829P .
6. Day CL, Puthalakath H, Skea G, Strasser A, Barsukov I, Lian LY, Huang DC, Hinds MG . Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands . The Biochemical Journal . 377 . Pt 3 . 597–605 . February 2004 . 14561217 . 1223895 . 10.1042/BJ20031251 .