DVL3 explained

Segment polarity protein dishevelled homolog DVL-3 is a protein that in humans is encoded by the DVL3 gene.^{[1] [2]}

This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation.

Interactions

DVL3 has been shown to interact with DAB2,^[3] DVL1^[4] and PRPF3.^[5]

See also

• Dishevelled

Further reading

• Nagase T, Seki N, Ishikawa K . Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain . DNA Res. . 3 . 5 . 321–329, 341–54 . 1997 . 9039502 . 10.1093/dnares/3.5.321 . etal. free .
• Semënov MV, Snyder M . Human dishevelled genes constitute a DHR-containing multigene family . Genomics . 42 . 2 . 302–310 . 1997 . 9192851 . 10.1006/geno.1997.4713 . free .
• Bui TD, Beier DR, Jonssen M . cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas . Biochem. Biophys. Res. Commun. . 239 . 2 . 510–516 . 1997 . 9344861 . 10.1006/bbrc.1997.7500 . etal.
• Kishida S, Yamamoto H, Hino S . DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability . Mol. Cell. Biol. . 19 . 6 . 4414–4422 . 1999 . 10330181 . 10.1128/mcb.19.6.4414. 104400 . etal.
• Song DH, Sussman DJ, Seldin DC . Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells . J. Biol. Chem. . 275 . 31 . 23790–23797 . 2000 . 10806215 . 10.1074/jbc.M909107199 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal. 2002PNAS...9916899M . free .
• Hocevar BA, Mou F, Rennolds JL . Regulation of the Wnt signaling pathway by disabled-2 (Dab2) . EMBO J. . 22 . 12 . 3084–3094 . 2003 . 12805222 . 10.1093/emboj/cdg286 . 162138 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–45 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Torban E, Wang HJ, Groulx N, Gros P . Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family . J. Biol. Chem. . 279 . 50 . 52703–52713 . 2005 . 15456783 . 10.1074/jbc.M408675200 . free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–1178 . 2005 . 16189514 . 10.1038/nature04209 . etal. 2005Natur.437.1173R . 4427026 .
• Chan DW, Chan CY, Yam JW . Prickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancer . Gastroenterology . 131 . 4 . 1218–1227 . 2006 . 17030191 . 10.1053/j.gastro.2006.07.020 . etal. free .

Notes and References

1. Pizzuti A, Amati F, Calabrese G, Mari A, Colosimo A, Silani V, Giardino L, Ratti A, Penso D, Calza L, Palka G, Scarlato G, Novelli G, Dallapiccola B . cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene . Hum Mol Genet . 5 . 7 . 953–958 . January 1997 . 8817329 . 10.1093/hmg/5.7.953 . free .
2. Web site: Entrez Gene: DVL3 dishevelled, dsh homolog 3 (Drosophila).
3. Hocevar . B A . Mou F . Rennolds J L . Morris S M . Cooper J A . Howe P H . June 2003 . Regulation of the Wnt signaling pathway by disabled-2 (Dab2) . EMBO J. . 22 . 12 . 3084–3094 . England. 0261-4189. 12805222 . 10.1093/emboj/cdg286 . 162138 .
4. Kishida . S . Yamamoto H . Hino S . Ikeda S . Kishida M . Kikuchi A . June 1999 . DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability . Mol. Cell. Biol. . 19 . 6 . 4414–4422 . UNITED STATES. 0270-7306. 10330181 . 104400 . 10.1128/mcb.19.6.4414.
5. Rual . Jean-François . Venkatesan Kavitha . Hao Tong . Hirozane-Kishikawa Tomoko . Dricot Amélie . Li Ning . Berriz Gabriel F . Gibbons Francis D . Dreze Matija . Ayivi-Guedehoussou Nono . Klitgord Niels . Simon Christophe . Boxem Mike . Milstein Stuart . Rosenberg Jennifer . Goldberg Debra S . Zhang Lan V . Wong Sharyl L . Franklin Giovanni . Li Siming . Albala Joanna S . Lim Janghoo . Fraughton Carlene . Llamosas Estelle . Cevik Sebiha . Bex Camille . Lamesch Philippe . Sikorski Robert S . Vandenhaute Jean . Zoghbi Huda Y . Smolyar Alex . Bosak Stephanie . Sequerra Reynaldo . Doucette-Stamm Lynn . Cusick Michael E . Hill David E . Roth Frederick P . Vidal Marc . October 2005 . Towards a proteome-scale map of the human protein-protein interaction network . . 437 . 7062 . 1173–1178 . England. 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .