DVL2 explained

Segment polarity protein dishevelled homolog DVL-2 is a protein that in humans is encoded by the DVL2 gene.^[1]

This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.^[2]

Interactions

DVL2 has been shown to interact with Zinc finger protein 165,^[3] DAB2^[4] and Arrestin beta 1.^[5]

See also

• Dishevelled

Further reading

• Pizzuti A, Amati F, Calabrese G . cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene . Hum. Mol. Genet. . 5 . 7 . 953–8 . 1997 . 8817329 . 10.1093/hmg/5.7.953 . etal. free .
• Klingensmith J, Yang Y, Axelrod JD . Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2 . Mech. Dev. . 58 . 1–2 . 15–26 . 1997 . 8887313 . 10.1016/S0925-4773(96)00549-7 . 16004832 . etal. free .
• Semënov MV, Snyder M . Human dishevelled genes constitute a DHR-containing multigene family . Genomics . 42 . 2 . 302–10 . 1997 . 9192851 . 10.1006/geno.1997.4713 . free .
• Strovel ET, Wu D, Sussman DJ . Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription . J. Biol. Chem. . 275 . 4 . 2399–403 . 2000 . 10644691 . 10.1074/jbc.275.4.2399 . free .
• Song DH, Sussman DJ, Seldin DC . Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells . J. Biol. Chem. . 275 . 31 . 23790–7 . 2000 . 10806215 . 10.1074/jbc.M909107199 . free .
• Zhang Y, Neo SY, Han J, Lin SC . Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinase . J. Biol. Chem. . 275 . 32 . 25008–14 . 2000 . 10829020 . 10.1074/jbc.M002491200 . free .
• Chen W, Hu LA, Semenov MV . β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins . Proc. Natl. Acad. Sci. U.S.A. . 98 . 26 . 14889–94 . 2002 . 11742073 . 10.1073/pnas.211572798 . 64954 . etal. 2001PNAS...9814889C . free .
• Habas R, Kato Y, He X . Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1 . Cell . 107 . 7 . 843–54 . 2002 . 11779461 . 10.1016/S0092-8674(01)00614-6 . 16894557 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal. 2002PNAS...9916899M . free .
• Habas R, Dawid IB, He X . Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation . Genes Dev. . 17 . 2 . 295–309 . 2003 . 12533515 . 10.1101/gad.1022203 . 195976 .
• Chen W, ten Berge D, Brown J . Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4 . Science . 301 . 5638 . 1391–4 . 2003 . 12958364 . 10.1126/science.1082808 . etal. 2003Sci...301.1391C . 34975427 .
• Wong CK, Luo W, Deng Y . The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms . J. Biol. Chem. . 279 . 38 . 39366–73 . 2004 . 15262978 . 10.1074/jbc.M404598200 . etal. free .
• Torban E, Wang HJ, Groulx N, Gros P . Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family . J. Biol. Chem. . 279 . 50 . 52703–13 . 2005 . 15456783 . 10.1074/jbc.M408675200 . free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . etal. 2005Natur.437.1173R . 4427026 .
• Zhang L, Gao X, Wen J . Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation . J. Biol. Chem. . 281 . 13 . 8607–12 . 2006 . 16446366 . 10.1074/jbc.M600274200 . etal. free .
• Lim J, Hao T, Shaw C . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . etal. free .

Notes and References

1. Greco TL, Sussman DJ, Camper SA . Dishevelled-2 maps to human chromosome 17 and distal to Wnt3a and vestigial tail (vt) on mouse chromosome 11 . Mamm Genome . 7 . 6 . 475–6 . January 1997. 8662242 . 10.1007/s003359900144 . 39619679 .
2. Web site: Entrez Gene: DVL2 dishevelled, dsh homolog 2 (Drosophila).
3. Rual . Jean-François . Venkatesan Kavitha . Hao Tong . Hirozane-Kishikawa Tomoko . Dricot Amélie . Li Ning . Berriz Gabriel F . Gibbons Francis D . Dreze Matija . Ayivi-Guedehoussou Nono . Klitgord Niels . Simon Christophe . Boxem Mike . Milstein Stuart . Rosenberg Jennifer . Goldberg Debra S . Zhang Lan V . Wong Sharyl L . Franklin Giovanni . Li Siming . Albala Joanna S . Lim Janghoo . Fraughton Carlene . Llamosas Estelle . Cevik Sebiha . Bex Camille . Lamesch Philippe . Sikorski Robert S . Vandenhaute Jean . Zoghbi Huda Y . Smolyar Alex . Bosak Stephanie . Sequerra Reynaldo . Doucette-Stamm Lynn . Cusick Michael E . Hill David E . Roth Frederick P . Vidal Marc . October 2005. Towards a proteome-scale map of the human protein-protein interaction network . . 437 . 7062 . 1173–8 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
4. Hocevar . B A . Mou F . Rennolds J L . Morris S M . Cooper J A . Howe P H . June 2003. Regulation of the Wnt signaling pathway by disabled-2 (Dab2) . EMBO J. . 22 . 12 . 3084–94 . 0261-4189. 12805222 . 10.1093/emboj/cdg286 . 162138 .
5. Chen . W . Hu L A . Semenov M V . Yanagawa S . Kikuchi A . Lefkowitz R J . Miller W E . December 2001. β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins . . 98 . 26 . 14889–94 . 0027-8424. 11742073 . 10.1073/pnas.211572798 . 2001PNAS...9814889C . 64954 . free .