DUSP12 explained

Dual specificity protein phosphatase 12 is an enzyme that in humans is encoded by the DUSP12 gene.^{[1] [2]}

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation.

Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.

This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.

Further reading

• Hasstedt SJ, Chu WS, Das SK . Type 2 diabetes susceptibility genes on chromosome 1q21-24. . Ann. Hum. Genet. . 72 . Pt 2 . 163–9 . 2008. 18269685 . 10.1111/j.1469-1809.2007.00416.x . 272577 . etal. free .
• Das SK, Chu WS, Hale TC . Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes. . Diabetes . 55 . 9 . 2631–9 . 2006 . 16936214 . 10.2337/db05-1369 . 24401721 . etal. free .
• Gregory SG, Barlow KF, McLay KE . The DNA sequence and biological annotation of human chromosome 1. . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . etal. free .
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . etal . 2005Natur.437.1173R. 4427026 .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal . 2002PNAS...9916899M. free .
• Groom LA, Sneddon AA, Alessi DR . Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase. . EMBO J. . 15 . 14 . 3621–32 . 1996 . 8670865 . 10.1002/j.1460-2075.1996.tb00731.x. 451978 . etal.

Notes and References

1. Muda M, Manning ER, Orth K, Dixon JE . Identification of the human YVH1 protein-tyrosine phosphatase orthologue reveals a novel zinc binding domain essential for in vivo function . J Biol Chem . 274 . 34 . 23991–5 . Sep 1999 . 10446167 . 10.1074/jbc.274.34.23991 . free .
2. Web site: Entrez Gene: DUSP12 dual specificity phosphatase 12.