DUSP10 explained

Dual specificity protein phosphatase 10 is an enzyme that in humans is encoded by the DUSP10 gene.^{[1] [2] [3]}

Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene.

Interactions

DUSP10 has been shown to interact with MAPK14^{[4] [5] [6]} and MAPK8.^[1]

Further reading

• Martell KJ, Angelotti T, Ullrich A . The "VH1-like" dual-specificity protein tyrosine phosphatases. . Mol. Cells . 8 . 1 . 2–11 . 1998 . 10.1016/S1016-8478(23)13385-1 . 9571625 . free .
• Teng CH, Huang WN, Meng TC . Several dual specificity phosphatases coordinate to control the magnitude and duration of JNK activation in signaling response to oxidative stress. . J. Biol. Chem. . 282 . 39 . 28395–407 . 2007 . 17681939 . 10.1074/jbc.M705142200 . free .
• Tao X, Tong L . Crystal structure of the MAP kinase binding domain and the catalytic domain of human MKP5. . Protein Sci. . 16 . 5 . 880–6 . 2007 . 17400920 . 10.1110/ps.062712807 . 2206639 .
• Nonn L, Duong D, Peehl DM . Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells. . Carcinogenesis . 28 . 6 . 1188–96 . 2007 . 17151092 . 10.1093/carcin/bgl241 . free .
• Jeong DG, Yoon TS, Kim JH . Crystal structure of the catalytic domain of human MAP kinase phosphatase 5: structural insight into constitutively active phosphatase. . J. Mol. Biol. . 360 . 5 . 946–55 . 2006 . 16806267 . 10.1016/j.jmb.2006.05.059 . etal.
• Gregory SG, Barlow KF, McLay KE . The DNA sequence and biological annotation of human chromosome 1. . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . etal. 2006Natur.441..315G . free .
• Nousiainen M, Silljé HH, Sauer G . Phosphoproteome analysis of the human mitotic spindle. . Proc. Natl. Acad. Sci. U.S.A. . 103 . 14 . 5391–6 . 2006 . 16565220 . 10.1073/pnas.0507066103 . 1459365 . etal. 2006PNAS..103.5391N . free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal. 2002PNAS...9916899M . free .
• Tanoue T, Yamamoto T, Maeda R, Nishida E . A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs. . J. Biol. Chem. . 276 . 28 . 26629–39 . 2001 . 11359773 . 10.1074/jbc.M101981200 . free .
• Masuda K, Shima H, Kikuchi K . Expression and comparative chromosomal mapping of MKP-5 genes DUSP10/Dusp10. . Cytogenet. Cell Genet. . 90 . 1–2 . 71–4 . 2000 . 11060451 . 10.1159/000015666 . 30344543 . etal.

Notes and References

1. Tanoue T, Moriguchi T, Nishida E . Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5 . J Biol Chem . 274 . 28 . 19949–56 . Aug 1999 . 10391943 . 10.1074/jbc.274.28.19949 . free .
2. Theodosiou A, Smith A, Gillieron C, Arkinstall S, Ashworth A . MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases . Oncogene . 18 . 50 . 6981–8 . Jan 2000 . 10597297 . 10.1038/sj.onc.1203185 . free .
3. Web site: Entrez Gene: DUSP10 dual specificity phosphatase 10.
4. 10.1074/jbc.274.28.19949 . Tanoue . T . Moriguchi T . Nishida E . Jul 1999 . Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5 . J. Biol. Chem. . 274 . 28 . 19949–56 . UNITED STATES. 0021-9258. 10391943 . free .
5. Tanoue . T . Yamamoto T . Maeda R . Nishida E . Jul 2001 . A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs . J. Biol. Chem. . 276 . 28 . 26629–39 . United States. 0021-9258. 11359773 . 10.1074/jbc.M101981200 . free .
6. Tanoue . T . Maeda R . Adachi M . Nishida E . Feb 2001 . Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions . EMBO J. . 20 . 3 . 466–79 . England. 0261-4189. 11157753 . 10.1093/emboj/20.3.466 . 133461 .