DTaP-IPV/Hib vaccine explained

DTaP-IPV/Hib vaccine is a 5-in-1 combination vaccine that protects against diphtheria, tetanus, whooping cough, polio, and Haemophilus influenzae type B.[1] [2]

Its generic name is "diphtheria and tetanus toxoids and acellular pertussis adsorbed, inactivated poliovirus and haemophilus B conjugate vaccine", and it is also known as DTaP-IPV-Hib.[1]

Uses

DTaP-IPV/Hib vaccine is administered to young children to immunise against diphtheria, tetanus, pertussis, poliomyelitis, and diseases caused by Haemophilus influenzae type B.[1]

Formulations

A branded formulation marketed in the United States is Pentacel, manufactured by Sanofi Pasteur.[3]

Pentacel is known in the UK and Canada as Pediacel.[4] [5]

An equivalent vaccine marketed in the UK and Canada by GlaxoSmithKline is Infanrix IPV + Hib. This is a two-part vaccine. The DTaP-IPV component is supplied as a sterile liquid, which is used to reconstitute lyophilized (freeze-dried) Hib vaccine.

Pentaxim is a liquid formulation marketed by Sanofi Pasteur.[6]

Availability

It is only licensed for young children.[7] The United States Food and Drug Administration has approved the vaccine for children from age 6 weeks up to age 5 years.[1] It was used in the UK until 2017, following which a 6-in-1 vaccine became available containing the additional protection against Hepatitis B.[2]

Notes and References

  1. Web site: Diphtheria and Tetanus Toxoids, Acellular Pertussis, Poliovirus and Haemophilus b Conjugate Vaccine. Drugs.com. 15 July 2018.
  2. Web site: 5-in-1 Vaccine (also called Pentavalent Vaccine). 3 July 2018. Vaccine Knowledge Project. 3 January 2021.
  3. Web site: Pentacel. U.S. Food and Drug Administration(FDA) . 15 July 2018 . STN 125145.
  4. Web site: Pediacel syringe - Summary of Product Characteristics (SmPC) . Datapharm . 17 Apr 2019 . https://web.archive.org/web/20191017041646/https://www.medicines.org.uk/emc/product/4017/smpc . 17 October 2019 . live . 16 October 2019.
  5. Web site: Diphteria Toxoid: Canadian Immunization Guide . Public Health Agency of Canada . December 2014 . https://web.archive.org/web/20190924101920/https://www.canada.ca/en/public-health/services/publications/healthy-living/canadian-immunization-guide-part-4-active-vaccines/page-4-diphtheria-toxoid.html . 24 September 2019 . live . 16 October 2019.
  6. Plotkin SA, Liese J, Madhi SA, Ortiz E . A DTaP-IPV//PRP~T vaccine (Pentaxim): a review of 16 years' clinical experience . Expert Rev Vaccines . 10 . 7 . 981–1005 . July 2011 . 21749196 . 10.1586/erv.11.72 . 207224675 .
  7. Web site: Diphtheria toxoid / haemophilus b conjugate (prp-t) vaccine / pertussis, acellular / poliovirus vaccine, inactivated / tetanus toxoid (Pentacel) Use During Pregnancy . Drugs.com . 2 January 2021 . en.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "DTaP-IPV/Hib vaccine".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.