DTYMK explained

Thymidylate kinase also known as deoxythymidylate kinase or dTMP kinase is an enzyme that in humans is encoded by the DTYMK gene.^{[1] [2] [3]} and belongs to thymidylate kinase family of proteins.

Further reading

• Van Rompay AR, Johansson M, Karlsson A . Phosphorylation of nucleosides and nucleoside analogs by mammalian nucleoside monophosphate kinases. . Pharmacol. Ther. . 87 . 2–3 . 189–98 . 2000 . 11008000 . 10.1016/S0163-7258(00)00048-6 .
• Tamiya N, Yusa T, Yamaguchi Y . Co-purification of thymidylate kinase and cytosolic thymidine kinase from human term placenta by affinity chromatography. . Biochim. Biophys. Acta . 995 . 1 . 28–35 . 1989 . 2538159 . 10.1016/0167-4838(89)90229-X . etal.
• Cummins RR, Balinsky D . Activities of some enzymes of pyrimidine and DNA synthesis in a rat transplantable hepatoma and human primary hepatomas, in cell lines derived from these tissues, and in human fetal liver. . Cancer Res. . 40 . 4 . 1235–9 . 1980 . 6244089 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ostermann N, Segura-Peña D, Meier C . Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds. . Biochemistry . 42 . 9 . 2568–77 . 2003 . 12614151 . 10.1021/bi027302t . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.

Notes and References

1. Su JY, Sclafani RA . Molecular cloning and expression of the human deoxythymidylate kinase gene in yeast . Nucleic Acids Res . 19 . 4 . 823–7 . May 1991 . 2017365 . 333717 . 10.1093/nar/19.4.823 .
2. Huang SH, Tang A, Drisco B, Zhang SQ, Seeger R, Li C, Jong A . Human dTMP kinase: gene expression and enzymatic activity coinciding with cell cycle progression and cell growth . DNA Cell Biol . 13 . 5 . 461–71 . Aug 1994 . 8024690 . 10.1089/dna.1994.13.461 .
3. Web site: Entrez Gene: DTYMK deoxythymidylate kinase (thymidylate kinase).