DTX1 explained

Protein deltex-1 is a protein that in humans is encoded by the DTX1 gene.^{[1] [2]}

Function

Studies in Drosophila have identified this gene as encoding a positive regulator of the notch signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity.

Interactions

DTX1 has been shown to interact with EP300.^[3]

Further reading

• Saito T, Chiba S, Ichikawa M, Kunisato A, Asai T, Shimizu K, Yamaguchi T, Yamamoto G, Seo S, Kumano K, Nakagami-Yamaguchi E, Hamada Y, Aizawa S, Hirai H . Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development . Immunity . 18 . 5 . 675–85 . May 2003 . 12753744 . 10.1016/S1074-7613(03)00111-0 . free .
• Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA . The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity . The Journal of Biological Chemistry . 278 . 24 . 21930–7 . Jun 2003 . 12670957 . 10.1074/jbc.M301157200 . free .
• Gupta-Rossi N, Storck S, Griebel PJ, Reynaud CA, Weill JC, Dahan A . Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells . Molecular Immunology . 39 . 13 . 791–9 . Mar 2003 . 12617994 . 10.1016/S0161-5890(03)00002-6 .
• Izon DJ, Aster JC, He Y, Weng A, Karnell FG, Patriub V, Xu L, Bakkour S, Rodriguez C, Allman D, Pear WS . Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1 . Immunity . 16 . 2 . 231–43 . Feb 2002 . 11869684 . 10.1016/S1074-7613(02)00271-6 . free .
• Yamamoto N, Yamamoto S, Inagaki F, Kawaichi M, Fukamizu A, Kishi N, Matsuno K, Nakamura K, Weinmaster G, Okano H, Nakafuku M . Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor . The Journal of Biological Chemistry . 276 . 48 . 45031–40 . Nov 2001 . 11564735 . 10.1074/jbc.M105245200 . free .
• Kishi N, Tang Z, Maeda Y, Hirai A, Mo R, Ito M, Suzuki S, Nakao K, Kinoshita T, Kadesch T, Hui C, Artavanis-Tsakonas S, Okano H, Matsuno K . Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis . International Journal of Developmental Neuroscience . 19 . 1 . 21–35 . Feb 2001 . 11226752 . 10.1016/S0736-5748(00)00071-X . 21859491 .
• Lee L, Dowhanick-Morrissette J, Katz A, Jukofsky L, Krantz ID . Chromosomal localization, genomic characterization, and mapping to the Noonan syndrome critical region of the human Deltex (DTX1) gene . Human Genetics . 107 . 6 . 577–81 . Dec 2000 . 11153911 . 10.1007/s004390000431 . 38695463 .
• Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S . Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane . Cell . 90 . 2 . 281–91 . Jul 1997 . 9244302 . 10.1016/S0092-8674(00)80336-0 . 16544864 . free .
• Matsuno K, Diederich RJ, Go MJ, Blaumueller CM, Artavanis-Tsakonas S . Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats . Development . 121 . 8 . 2633–44 . Aug 1995 . 10.1242/dev.121.8.2633 . 7671825 .
• Scalia . Pierluigi . Williams . Stephen J. . Suma . Antonio . Carnevale . Vincenzo . 2023-06-21 . The DTX Protein Family: An Emerging Set of E3 Ubiquitin Ligases in Cancer . Cells . 12 . 13 . 1680 . 10.3390/cells12131680 . free . 2073-4409 . 37443713. 10340142 .

Notes and References

1. Matsuno K, Eastman D, Mitsiades T, Quinn AM, Carcanciu ML, Ordentlich P, Kadesch T, Artavanis-Tsakonas S . Human deltex is a conserved regulator of Notch signalling . Nature Genetics . 19 . 1 . 74–8 . May 1998 . 9590294 . 10.1038/ng0598-74 . 6812613 .
2. Web site: Entrez Gene: DTX1 deltex homolog 1 (Drosophila).
3. Yamamoto N, Yamamoto S, Inagaki F, Kawaichi M, Fukamizu A, Kishi N, Matsuno K, Nakamura K, Weinmaster G, Okano H, Nakafuku M . Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor . The Journal of Biological Chemistry . 276 . 48 . 45031–40 . Nov 2001 . 11564735 . 10.1074/jbc.M105245200 . free .