Dystrobrevin beta explained

Dystrobrevin beta is a protein which in humans is encoded by the DTNB gene.^[1]

Function

This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. Alternatively spliced transcript variants encoding different isoforms have been identified.^[2]

Further reading

• Blake DJ, Hawkes R, Benson MA, Beesley PW . Different dystrophin-like complexes are expressed in neurons and glia. . J. Cell Biol. . 147 . 3 . 645–58 . 1999 . 10545507 . 10.1083/jcb.147.3.645 . 2151186 .
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Yu W, Andersson B, Worley KC . Large-scale concatenation cDNA sequencing. . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 10.1101/gr.7.4.353. 139146 . etal.
• Piluso G, Mirabella M, Ricci E . Gamma1- and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells. . J. Biol. Chem. . 275 . 21 . 15851–60 . 2000 . 10747910 . 10.1074/jbc.M000439200 . etal. free .
• Puca AA, Nigro V, Piluso G . Identification and characterization of a novel member of the dystrobrevin gene family. . FEBS Lett. . 425 . 1 . 7–13 . 1998 . 9540997 . 10.1016/S0014-5793(98)00097-0 . 31934419 . etal.
• Macioce P, Gambara G, Bernassola M . Beta-dystrobrevin interacts directly with kinesin heavy chain in brain. . J. Cell Sci. . 116 . Pt 23 . 4847–56 . 2003 . 14600269 . 10.1242/jcs.00805 . 27097248 . etal.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . etal.
• Straub V, Campbell KP . Muscular dystrophies and the dystrophin-glycoprotein complex. . Curr. Opin. Neurol. . 10 . 2 . 168–75 . 1997 . 9146999 . 10.1097/00019052-199704000-00016 . free .
• Nazarian R, Starcevic M, Spencer MJ, Dell'Angelica EC . Reinvestigation of the dysbindin subunit of BLOC-1 (biogenesis of lysosome-related organelles complex-1) as a dystrobrevin-binding protein. . Biochem. J. . 395 . 3 . 587–98 . 2006 . 16448387 . 10.1042/BJ20051965 . 1462696 .
• Gudbjartsson DF, Walters GB, Thorleifsson G . Many sequence variants affecting diversity of adult human height. . Nat. Genet. . 40 . 5 . 609–15 . 2008 . 18391951 . 10.1038/ng.122 . 3005450 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Albrecht DE, Froehner SC . DAMAGE, a novel alpha-dystrobrevin-associated MAGE protein in dystrophin complexes. . J. Biol. Chem. . 279 . 8 . 7014–23 . 2004 . 14623885 . 10.1074/jbc.M312205200 . free .
• Peters MF, O'Brien KF, Sadoulet-Puccio HM . beta-dystrobrevin, a new member of the dystrophin family. Identification, cloning, and protein associations. . J. Biol. Chem. . 272 . 50 . 31561–9 . 1997 . 9395493 . 10.1074/jbc.272.50.31561 . etal. free .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Andersson B, Wentland MA, Ricafrente JY . A "double adaptor" method for improved shotgun library construction. . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Benson MA, Newey SE, Martin-Rendon E . Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain. . J. Biol. Chem. . 276 . 26 . 24232–41 . 2001 . 11316798 . 10.1074/jbc.M010418200 . etal. free .
• Hillman RT, Green RE, Brenner SE . An unappreciated role for RNA surveillance. . Genome Biol. . 5 . 2 . R8 . 2004 . 14759258 . 10.1186/gb-2004-5-2-r8 . 395752 . free .

Notes and References

1. Blake DJ, Nawrotzki R, Loh NY, Górecki DC, Davies KE . beta-dystrobrevin, a member of the dystrophin-related protein family . Proc. Natl. Acad. Sci. U.S.A. . 95 . 1 . 241–6 . January 1998 . 9419360 . 18188 . 10.1073/pnas.95.1.241. 1998PNAS...95..241B . free .
2. Web site: Entrez Gene: DTNB dystrobrevin, beta.