DTL (gene) explained

Denticleless protein homolog is a protein that in humans is encoded by the DTL gene.^{[1] [2]}

Interactions

DTL (gene) has been shown to interact with P21.^[3]

Further reading

• Banks D, Wu M, Higa LA, Gavrilova N, Quan J, Ye T, Kobayashi R, Sun H, Zhang H . L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes. . Cell Cycle . 5 . 15 . 1719–29 . 2007 . 16861890 . 10.4161/cc.5.15.3150 . free .
• Higa LA, Banks D, Wu M, Kobayashi R, Sun H, Zhang H . L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage. . Cell Cycle . 5 . 15 . 1675–80 . 2007 . 16861906 . 10.4161/cc.5.15.3149 . free .
• Jin J, Arias EE, Chen J, Harper JW, Walter JC . A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. . Mol. Cell . 23 . 5 . 709–21 . 2006 . 16949367 . 10.1016/j.molcel.2006.08.010 . free .
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP . A probability-based approach for high-throughput protein phosphorylation analysis and site localization. . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• Higa LA, Wu M, Ye T, Kobayashi R, Sun H, Zhang H . CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. . Nat. Cell Biol. . 8 . 11 . 1277–83 . 2006 . 17041588 . 10.1038/ncb1490 . 22180568 . 10397/34293 . free .
• Sansam CL, Shepard JL, Lai K, Ianari A, Danielian PS, Amsterdam A, Hopkins N, Lees JA . DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint. . Genes Dev. . 20 . 22 . 3117–29 . 2006 . 17085480 . 1635147 . 10.1101/gad.1482106 .
• Pan HW, Chou HY, Liu SH, Peng SY, Liu CL, Hsu HC . Role of L2DTL, cell cycle-regulated nuclear and centrosome protein, in aggressive hepatocellular carcinoma. . Cell Cycle . 5 . 22 . 2676–87 . 2007 . 17106265 . 10.4161/cc.5.22.3500 . free .

Notes and References

1. Cheung WM, Chu AH, Chu PW, Ip NY . Cloning and expression of a novel nuclear matrix-associated protein that is regulated during the retinoic acid-induced neuronal differentiation . J Biol Chem . 276 . 20 . 17083–91 . May 2001 . 11278750 . 10.1074/jbc.M010802200 . free .
2. Web site: Entrez Gene: DTL denticleless homolog (Drosophila).
3. Abbas T, Sivaprasad U, Terai K, Amador V, Pagano M, Dutta A . PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex . Genes Dev. . 22 . 18 . 2496–506 . Sep 2008 . 18794347 . 2546691 . 10.1101/gad.1676108 .