DTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+) explained

DTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+)
Ec Number:1.1.1.339

DTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+) (tll (gene name)) is an enzyme with systematic name dTDP-6-deoxy-beta-L-talose:NAD+ 4-oxidoreductase.[1] This enzyme catalyses the following chemical reaction

dTDP-6-deoxy-beta-L-talose + NAD+

\rightleftharpoons

dTDP-4-dehydro-6-deoxy-beta-L-mannose + NADH + H+

The enzyme from bacterium Aggregatibacter actinomycetemcomitans participates in the biosynthesis of the serotype c-specific polysaccharide antigen.

Notes and References

  1. Nakano Y, Suzuki N, Yoshida Y, Nezu T, Yamashita Y, Koga T . Thymidine diphosphate-6-deoxy-L-lyxo-4-hexulose reductase synthesizing dTDP-6-deoxy-L-talose from Actinobacillus actinomycetemcomitans . The Journal of Biological Chemistry . 275 . 10 . 6806–12 . March 2000 . 10702238 . 10.1074/jbc.275.10.6806 . free .