| dTDP-4-dehydrorhamnose reductase | |
| Ec Number: | 1.1.1.133 |
| Cas Number: | 37250-64-9 |
| Go Code: | 0008831 |
In enzymology, a dTDP-4-dehydrorhamnose reductase is an enzyme that catalyzes the chemical reaction
dTDP-6-deoxy-L-mannose + NADP+
\rightleftharpoons
Thus, the two substrates of this enzyme are dTDP-6-deoxy-L-mannose and NADP+, whereas its 3 products are dTDP-4-dehydro-6-deoxy-L-mannose, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is dTDP-6-deoxy-L-mannose:NADP+ 4-oxidoreductase. Other names in common use include dTDP-4-keto-L-rhamnose reductase, reductase, thymidine diphospho-4-ketorhamnose, dTDP-4-ketorhamnose reductase, TDP-4-keto-rhamnose reductase, and thymidine diphospho-4-ketorhamnose reductase. This enzyme participates in 3 metabolic pathways: nucleotide sugars metabolism, streptomycin biosynthesis, and polyketide sugar unit biosynthesis.
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes,,,, and .