DSN1 explained

DSN1, MIND kinetochore complex component, homolog (S. cerevisiae), also known as DSN1 or MIS13, is a protein which in humans encoded by the DSN1 gene.^{[1] [2]}

Function

DSN1 along with MIS12, DC8, PMF1, CBX5, ZWINT is a component of the kinetochore-associated multiprotein complex which is required for correct chromosome alignment during the metaphase of cell mitosis.^{[2] [3]}

Interactions

DSN1 has been shown to interact with NSL1^[4] and MIS12.^{[2] [5]}

Further reading

• Olsen JV, Blagoev B, Gnad F . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . etal. free .
• Kline SL, Cheeseman IM, Hori T . The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation. . J. Cell Biol. . 173 . 1 . 9–17 . 2006 . 16585270 . 10.1083/jcb.200509158 . 2063780 . etal.
• Nousiainen M, Silljé HH, Sauer G . Phosphoproteome analysis of the human mitotic spindle. . Proc. Natl. Acad. Sci. U.S.A. . 103 . 14 . 5391–6 . 2006 . 16565220 . 10.1073/pnas.0507066103 . 1459365 . etal. 2006PNAS..103.5391N . free .
• Obuse C, Iwasaki O, Kiyomitsu T . A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. . Nat. Cell Biol. . 6 . 11 . 1135–41 . 2004 . 15502821 . 10.1038/ncb1187 . 39408000 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Cheeseman IM, Niessen S, Anderson S . A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. . Genes Dev. . 18 . 18 . 2255–68 . 2004 . 15371340 . 10.1101/gad.1234104 . 517519 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal. 2002PNAS...9916899M . free .
• Deloukas P, Matthews LH, Ashurst J . The DNA sequence and comparative analysis of human chromosome 20. . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . etal. 2001Natur.414..865D . free .

Notes and References

1. Web site: Entrez Gene: DSN1 DSN1, MIND kinetochore complex component, homolog (S. cerevisiae).
2. Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M . A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1 . Nat. Cell Biol. . 6 . 11 . 1135–41 . November 2004 . 15502821 . 10.1038/ncb1187 . 39408000 .
3. Yang Y, Wu F, Ward T, Yan F, Wu Q, Wang Z, McGlothen T, Peng W, You T, Sun M, Cui T, Hu R, Dou Z, Zhu J, Xie W, Rao Z, Ding X, Yao X . Phosphorylation of HsMis13 by Aurora B kinase is essential for assembly of functional kinetochore . J. Biol. Chem. . 283 . 39 . 26726–36 . September 2008 . 18640974 . 10.1074/jbc.M804207200 . 2546542 . free .
4. Obuse . Chikashi . Iwasaki Osamu . Kiyomitsu Tomomi . Goshima Gohta . Toyoda Yusuke . Yanagida Mitsuhiro . Nov 2004 . A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1 . Nat. Cell Biol. . 6 . 11 . 1135–41 . England. 1465-7392. 15502821 . 10.1038/ncb1187 . 39408000 .
5. Cheeseman . Iain M . Niessen Sherry . Anderson Scott . Hyndman Francie . Yates John R . Oegema Karen . Desai Arshad . Sep 2004 . A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension . Genes Dev. . 18 . 18 . 2255–68 . United States. 0890-9369. 15371340 . 10.1101/gad.1234104 . 517519 .