DPYSL5 explained

Dihydropyrimidinase-related protein 5 is an enzyme that in humans is encoded by the DPYSL5 gene.^{[1] [2] [3]}

Members of the CRMP family, such as DPYSL5, are believed to play a role in growth cone guidance during neural development.[supplied by OMIM]

Further reading

• Cross SA, Salomao DR, Parisi JE . Paraneoplastic autoimmune optic neuritis with retinitis defined by CRMP-5-IgG. . Ann. Neurol. . 54 . 1 . 38–50 . 2003 . 12838519 . 10.1002/ana.10587 . 36493404 . etal.
• Fukada M, Watakabe I, Yuasa-Kawada J . Molecular characterization of CRMP5, a novel member of the collapsin response mediator protein family. . J. Biol. Chem. . 275 . 48 . 37957–65 . 2001 . 10956643 . 10.1074/jbc.M003277200 . etal. free .
• Yu Z, Kryzer TJ, Griesmann GE . CRMP-5 neuronal autoantibody: marker of lung cancer and thymoma-related autoimmunity. . Ann. Neurol. . 49 . 2 . 146–54 . 2001 . 11220734 . 10.1002/1531-8249(20010201)49:2<146::AID-ANA34>3.0.CO;2-E . 3239861 . etal.
• Ricard D, Rogemond V, Charrier E . Isolation and expression pattern of human Unc-33-like phosphoprotein 6/collapsin response mediator protein 5 (Ulip6/CRMP5): coexistence with Ulip2/CRMP2 in Sema3a- sensitive oligodendrocytes. . J. Neurosci. . 21 . 18 . 7203–14 . 2001 . 11549731 . 6763003 . 10.1523/JNEUROSCI.21-18-07203.2001. etal.
• Mitsui N, Inatome R, Takahashi S . Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling. . EMBO J. . 21 . 13 . 3274–85 . 2002 . 12093729 . 10.1093/emboj/cdf328 . 125392 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.

Notes and References

1. Inatome R, Tsujimura T, Hitomi T, Mitsui N, Hermann P, Kuroda S, Yamamura H, Yanagi S . Identification of CRAM, a novel unc-33 gene family protein that associates with CRMP3 and protein-tyrosine kinase(s) in the developing rat brain . J Biol Chem . 275 . 35 . 27291–302 . Oct 2000 . 10851247 . 10.1074/jbc.M910126199 . free .
2. Horiuchi M, El Far O, Betz H . Ulip6, a novel unc-33 and dihydropyrimidinase related protein highly expressed in developing rat brain . FEBS Lett . 480 . 2–3 . 283–6 . Nov 2000 . 11034345 . 10.1016/S0014-5793(00)01952-9 . 42248702 . free .
3. Web site: Entrez Gene: DPYSL5 dihydropyrimidinase-like 5.