DPPA3 explained

Developmental pluripotency-associated protein 3 is a protein that in humans is encoded by the DPPA3 gene.^[1]

This gene encodes a protein that in mice may function as a maternal factor during the preimplantation stage of development. In mice, this gene may play a role in transcriptional repression, cell division, and maintenance of cell pluripotentiality. In humans, related intronless loci are located on chromosomes 14 and X.

Further reading

• Nakamura T, Arai Y, Umehara H . PGC7/Stella protects against DNA demethylation in early embryogenesis. . Nat. Cell Biol. . 9 . 1 . 64–71 . 2007 . 17143267 . 10.1038/ncb1519 . 1947132 . etal.
• Elliman SJ, Wu I, Kemp DM . Adult tissue-specific expression of a Dppa3-derived retrogene represents a postnatal transcript of pluripotent cell origin. . J. Biol. Chem. . 281 . 1 . 16–9 . 2006 . 16291741 . 10.1074/jbc.C500415200 . free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Bortvin A, Goodheart M, Liao M, Page DC . Dppa3 / Pgc7 / stella is a maternal factor and is not required for germ cell specification in mice. . BMC Dev. Biol. . 4. 2 . 2004 . 15018652 . 10.1186/1471-213X-4-2 . 362866 . free .
• Clark AT, Rodriguez RT, Bodnar MS . Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma. . Stem Cells . 22 . 2 . 169–79 . 2004 . 14990856 . 10.1634/stemcells.22-2-169 . 38136098 . etal. free .
• Bowles J, Teasdale RP, James K, Koopman P . Dppa3 is a marker of pluripotency and has a human homologue that is expressed in germ cell tumours. . Cytogenet. Genome Res. . 101 . 3–4 . 261–5 . 2004 . 14684992 . 10.1159/000074346 . 7005986 .
• Payer B, Saitou M, Barton SC . Stella is a maternal effect gene required for normal early development in mice . Curr. Biol. . 13 . 23 . 2110–7 . 2004 . 14654002 . 10.1016/j.cub.2003.11.026 . 2010581 . etal. free .
• Sato M, Kimura T, Kurokawa K . Identification of PGC7, a new gene expressed specifically in preimplantation embryos and germ cells . Mech. Dev. . 113 . 1 . 91–4 . 2002 . 11900980 . 10.1016/S0925-4773(02)00002-3 . 12877378 . etal.

Notes and References

1. Web site: Entrez Gene: DPPA3 developmental pluripotency associated 3.