DPP7 explained

Dipeptidyl-peptidase 2 is an enzyme that in humans is encoded by the DPP7 gene.^{[1] [2] [3]}

The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolyl carboxypeptidase and is active at both acidic and neutral pH.

Further reading

• Fornas E, Mayordomo F, Renau-Piqueras J, Alborch E . Effect of cholesterol and its autooxidation derivatives on endocytosis and dipeptidyl peptidases of aortic endothelial cells . Histol. Histopathol. . 7 . 2 . 163–8 . 1992 . 1515698 .
• Roberts VJ, Gorenstein C . The effect of antimitotic agents on the intraneuronal distribution of lysosomes . Brain Res. . 521 . 1–2 . 62–72 . 1990 . 2207678 . 10.1016/0006-8993(90)91525-L . 10381435 .
• Andersen KJ, McDonald JK . Lysosomal heterogeneity of dipeptidyl peptidase II active on collagen-related peptides . Ren. Physiol. Biochem. . 12 . 1 . 32–40 . 1989 . 2727382 . 10.1159/000173177.
• Demuth HU . Design of (omega-N-(O-acyl)hydroxy amid) aminodicarboxylic acid pyrrolidides as potent inhibitors of proline-specific peptidases . FEBS Lett. . 320 . 1 . 23–7 . 1993 . 8096464 . 10.1016/0014-5793(93)81649-K . Schlenzig D . Schierhorn A . Grosche . G . Chapotchartier . M . Gripon . J . 24505098 . free.
• Underwood R . Sequence, purification, and cloning of an intracellular serine protease, quiescent cell proline dipeptidase . J. Biol. Chem. . 274 . 48 . 34053–8 . 1999 . 10567372 . 10.1074/jbc.274.48.34053 . Chiravuri M . Lee H . Schmitz . T . Kabcenell . AK . Yardley . K . Huber . BT . free .
• Chiravuri M . Vesicular localization and characterization of a novel post-proline-cleaving aminodipeptidase, quiescent cell proline dipeptidase . J. Immunol. . 165 . 10 . 5695–702 . 2000 . 11067927 . 10.4049/jimmunol.165.10.5695. Agarraberes F . Mathieu SL . Lee . H . Huber . BT . free.
• Araki H . Purification, molecular cloning, and immunohistochemical localization of dipeptidyl peptidase II from the rat kidney and its identity with quiescent cell proline dipeptidase . J. Biochem. . 129 . 2 . 279–88 . 2001 . 11173530 . 10.1093/oxfordjournals.jbchem.a002855. Li Y . Yamamoto Y . Haneda . M . Nishi . K . Kikkawa . R . Ohkubo . I .
• Zhan H . Peptidases play an important role in cataractogenesis: an immunohistochemical study on lenses derived from Shumiya cataract rats . Histochem. J. . 33 . 9–10 . 511–21 . 2002 . 12005022 . 10.1023/A:1014943522613 . Yamamoto Y . Shumiya S . Kunimatsu . Mitoshi . Nishi . Katsuji . Ohkubo . Iwao . Kani . Kazutaka . 29588226 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Leiting B . Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII . Biochem. J. . 371 . Pt 2 . 525–32 . 2003 . 12529175 . 10.1042/BJ20021643 . 1223300 . Pryor KD . Wu JK . Marsilio . Frank . Patel . Reshma A. . Craik . Charles S. . Ellman . Jonathan A. . Cummings . Richard T. . Thornberry . Nancy A. .
• Lehner B, Sanderson CM . A Protein Interaction Framework for Human mRNA Degradation . Genome Res. . 14 . 7 . 1315–23 . 2004 . 15231747 . 10.1101/gr.2122004 . 442147 .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .

Notes and References

1. Chiravuri M, Schmitz T, Yardley K, Underwood R, Dayal Y, Huber BT . A novel apoptotic pathway in quiescent lymphocytes identified by inhibition of a post-proline cleaving aminodipeptidase: a candidate target protease, quiescent cell proline dipeptidase . J Immunol . 163 . 6 . 3092–9 . Oct 1999 . 10.4049/jimmunol.163.6.3092 . 10477574 . free .
2. Fukasawa KM, Fukasawa K, Higaki K, Shiina N, Ohno M, Ito S, Otogoto J, Ota N . Cloning and functional expression of rat kidney dipeptidyl peptidase II . Biochem J . 353 . Pt 2 . 283–90 . Jan 2001 . 11139392 . 1221570 . 10.1042/0264-6021:3530283 .
3. Web site: Entrez Gene: DPP7 dipeptidyl-peptidase 7.