DPP6 explained

Dipeptidyl aminopeptidase-like protein 6 is a protein that in humans is encoded by the DPP6 gene.^{[1] [2]}

This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[2]

Further reading

• Adams MD, Kerlavage AR, Fleischmann RD . Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. . Nature . 377 . 6547 Suppl . 3–174 . 1995 . 7566098 . etal.
• Yokotani N, Doi K, Wenthold RJ, Wada K . Non-conservation of a catalytic residue in a dipeptidyl aminopeptidase IV-related protein encoded by a gene on human chromosome 7. . Hum. Mol. Genet. . 2 . 7 . 1037–9 . 1993 . 8103397 . 10.1093/hmg/2.7.1037 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Toward a complete human genome sequence. . Genome Res. . 8 . 11 . 1097–108 . 1999 . 9847074 . 10.1101/gr.8.11.1097. Sanger Centre . The . Washington University Genome Sequencing Cente . The . free .
• Kin Y, Misumi Y, Ikehara Y . Biosynthesis and characterization of the brain-specific membrane protein DPPX, a dipeptidyl peptidase IV-related protein. . J. Biochem. . 129 . 2 . 289–95 . 2001 . 11173531 . 10.1093/oxfordjournals.jbchem.a002856.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Nadal MS, Ozaita A, Amarillo Y . The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a critical component of neuronal A-type K+ channels. . Neuron . 37 . 3 . 449–61 . 2003 . 12575952 . 10.1016/S0896-6273(02)01185-6 . 11494299 . etal. free .
• Hillier LW, Fulton RS, Fulton LA . The DNA sequence of human chromosome 7. . Nature . 424 . 6945 . 157–64 . 2003 . 12853948 . 10.1038/nature01782 . 2003Natur.424..157H . etal. free .
• Schmitt-Ulms G, Hansen K, Liu J . Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues. . Nat. Biotechnol. . 22 . 6 . 724–31 . 2005 . 15146195 . 10.1038/nbt969 . 36630738 . etal.
• Strop P, Bankovich AJ, Hansen KC . Structure of a human A-type potassium channel interacting protein DPPX, a member of the dipeptidyl aminopeptidase family. . J. Mol. Biol. . 343 . 4 . 1055–65 . 2004 . 15476821 . 10.1016/j.jmb.2004.09.003 . etal.
• Zagha E, Ozaita A, Chang SY . DPP10 modulates Kv4-mediated A-type potassium channels. . J. Biol. Chem. . 280 . 19 . 18853–61 . 2005 . 15671030 . 10.1074/jbc.M410613200 . etal. free .
• Radicke S, Cotella D, Graf EM . Expression and function of dipeptidyl-aminopeptidase-like protein 6 as a putative beta-subunit of human cardiac transient outward current encoded by Kv4.3. . J. Physiol. . 565 . Pt 3 . 751–6 . 2005 . 15890703 . 10.1113/jphysiol.2005.087312 . 1464568 . etal.
• Ren X, Hayashi Y, Yoshimura N, Takimoto K . Transmembrane interaction mediates complex formation between peptidase homologues and Kv4 channels. . Mol. Cell. Neurosci. . 29 . 2 . 320–32 . 2005 . 15911355 . 10.1016/j.mcn.2005.02.003 . 34065803 .
• Jerng HH, Kunjilwar K, Pfaffinger PJ . Multiprotein assembly of Kv4.2, KChIP3 and DPP10 produces ternary channel complexes with ISA-like properties. . J. Physiol. . 568 . Pt 3 . 767–88 . 2006 . 16123112 . 10.1113/jphysiol.2005.087858 . 1464192 .
• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . etal.
• Nadal MS, Amarillo Y, Vega-Saenz de Miera E, Rudy B . Differential characterization of three alternative spliced isoforms of DPPX. . Brain Res. . 1094 . 1 . 1–12 . 2006 . 16764835 . 10.1016/j.brainres.2006.03.106 . 33513405 .

Notes and References

1. Wada K, Yokotani N, Hunter C, Doi K, Wenthold RJ, Shimasaki S . Differential expression of two distinct forms of mRNA encoding members of a dipeptidyl aminopeptidase family . Proc Natl Acad Sci U S A . 89 . 1 . 197–201 . Feb 1992 . 1729689 . 48203 . 10.1073/pnas.89.1.197 . free .
2. Web site: Entrez Gene: DPP6 dipeptidyl-peptidase 6.