DPM3 explained

dolichyl-phosphate mannosyltransferase polypeptide 3, also known as DPM3, is a human gene.^{[1] [2]}

Function

Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a subunit of dolichyl-phosphate mannosyltransferase and acts as a stabilizer subunit of the dolichyl-phosphate mannosyltransferase complex.^[1]

Clinical significance

Mutations in this gene are associated with congenital disorder of glycosylation type 1O.^[3]

Further reading

• Maeda Y, Watanabe R, Harris CL . PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER. . EMBO J. . 20 . 1–2 . 250–61 . 2001 . 11226175 . 10.1093/emboj/20.1.250 . 140182. etal.
• Ashida H, Maeda Y, Kinoshita T . DPM1, the catalytic subunit of dolichol-phosphate mannose synthase, is tethered to and stabilized on the endoplasmic reticulum membrane by DPM3. . J. Biol. Chem. . 281 . 2 . 896–904 . 2006 . 16280320 . 10.1074/jbc.M511311200 . free .
• Maeda Y, Tanaka S, Hino J . Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3. . EMBO J. . 19 . 11 . 2475–82 . 2000 . 10835346 . 10.1093/emboj/19.11.2475 . 212771. etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . etal. free .
• Manos EJ, Kim ML, Kassis J . Dolichol-phosphate-mannose-3 (DPM3)/prostin-1 is a novel phospholipase C-gamma regulated gene negatively associated with prostate tumor invasion. . Oncogene . 20 . 22 . 2781–90 . 2001 . 11420690 . 10.1038/sj.onc.1204379 . etal. 24726733 .
• Gregory SG, Barlow KF, McLay KE . The DNA sequence and biological annotation of human chromosome 1. . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . etal. free .

External links

• GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview

Notes and References

1. Web site: Entrez Gene: dolichyl-phosphate mannosyltransferase polypeptide 3.
2. Maeda Y, Tanaka S, Hino J, Kangawa K, Kinoshita T . Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3 . EMBO J. . 19 . 11 . 2475–82 . June 2000 . 10835346 . 212771 . 10.1093/emboj/19.11.2475 .
3. Haeuptle MA, Hennet T . Congenital disorders of glycosylation: an update on defects affecting the biosynthesis of dolichol-linked oligosaccharides . Hum. Mutat. . 30 . 12 . 1628–41 . December 2009 . 19862844 . 10.1002/humu.21126 . 46281092 . 2019-12-11 . 2021-05-18 . https://web.archive.org/web/20210518201527/https://www.zora.uzh.ch/id/eprint/25758/4/Haeuptle_Hennet-HumMut_2009.pdf . dead .