2,5-Dimethoxy-4-trifluoromethylamphetamine (DOTFM) is a psychedelic drug of the phenethylamine and amphetamine chemical classes. It was first synthesized in 1994 by a team at Purdue University led by David E. Nichols.[1] DOTFM is the alpha-methylated analogue of 2C-TFM, and is around twice as potent in animal studies. It acts as an agonist at the 5-HT2A and 5-HT2C receptors.[1] In drug-substitution experiments in rats, DOTFM fully substituted for LSD and was slightly more potent than DOI.[1]