DOK5 explained

Docking protein 5 is a protein that in humans is encoded by the DOK5 gene.^[1]

Function

The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. In contrast to other DOK family proteins, this protein does not interact with RASGAP.^[2]

Interactions

DOK5 has been shown to interact with RET proto-oncogene.^[3]

Further reading

• Deloukas P, Matthews LH, Ashurst J . The DNA sequence and comparative analysis of human chromosome 20 . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . 2001Natur.414..865D . etal. free .
• Shi N, Zhou W, Tang K . Expression, crystallization and preliminary X-ray studies of the recombinant PTB domain of human dok-5 protein . Acta Crystallogr. D . 58 . Pt 12 . 2170–2 . 2003 . 12454490 . 10.1107/S090744490201644X . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Favre C, Gérard A, Clauzier E . DOK4 and DOK5: new Dok-related genes expressed in human T cells . Genes Immun. . 4 . 1 . 40–5 . 2003 . 12595900 . 10.1038/sj.gene.6363891 . etal. free .
• Cai D, Dhe-Paganon S, Melendez PA . Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5 . J. Biol. Chem. . 278 . 28 . 25323–30 . 2003 . 12730241 . 10.1074/jbc.M212430200 . etal. free .
• Crowder RJ, Enomoto H, Yang M . Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth . J. Biol. Chem. . 279 . 40 . 42072–81 . 2004 . 15286081 . 10.1074/jbc.M403726200 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Shi L, Yue J, You Y . Dok5 is substrate of TrkB and TrkC receptors and involved in neurotrophin induced MAPK activation . Cell. Signal. . 18 . 11 . 1995–2003 . 2007 . 16647839 . 10.1016/j.cellsig.2006.03.007 . etal.

Notes and References

1. Grimm J, Sachs M, Britsch S, Di Cesare S, Schwarz-Romond T, Alitalo K, Birchmeier W . Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation . J Cell Biol . 154 . 2 . 345–54 . Jul 2001 . 11470823 . 2150770 . 10.1083/jcb.200102032 .
2. Web site: Entrez Gene: DOK5 docking protein 5.
3. Crowder RJ, Enomoto H, Yang M, Johnson EM, Milbrandt J . Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth . J. Biol. Chem. . 279 . 40 . 42072–81 . 2004 . 15286081 . 10.1074/jbc.M403726200 . free .