DOC2A explained

Double C2-like domain-containing protein alpha is a protein that in humans is encoded by the DOC2A gene.^{[1] [2] [3]}

There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release.

Interactions

DOC2A has been shown to interact with UNC13B^{[2] [4]} and UNC13A.^[5]

Further reading

• Sakaguchi G, Orita S, Maeda M, Igarashi H, Takai Y . Molecular cloning of an isoform of Doc2 having two C2-like domains . Biochem. Biophys. Res. Commun. . 217 . 3 . 1053–61 . December 1995 . 8554557 . 10.1006/bbrc.1995.2876.
• Verhage M, de Vries KJ, Røshol H, Burbach JP, Gispen WH, Südhof TC . DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion . Neuron . 18 . 3 . 453–61 . March 1997 . 9115738 . 10.1016/S0896-6273(00)81245-3 . 17948539 . free .
• Nagano F, Orita S, Sasaki T, Naito A, Sakaguchi G, Maeda M, Watanabe T, Kominami E, Uchiyama Y, Takai Y . Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport . J. Biol. Chem. . 273 . 46 . 30065–8 . November 1998 . 9804756 . 10.1074/jbc.273.46.30065 . free .

Notes and References

1. Orita S, Sasaki T, Naito A, Komuro R, Ohtsuka T, Maeda M, Suzuki H, Igarashi H, Takai Y . Doc2: a novel brain protein having two repeated C2-like domains . Biochem Biophys Res Commun . 206 . 2 . 439–48 . Feb 1995 . 7826360 . 10.1006/bbrc.1995.1062 .
2. Mochida S, Orita S, Sakaguchi G, Sasaki T, Takai Y . Role of the Doc2α–Munc13–1 interaction in the neurotransmitter release process . Proc Natl Acad Sci U S A . 95 . 19 . 11418–22 . Oct 1998 . 9736751 . 21657 . 10.1073/pnas.95.19.11418 . 1998PNAS...9511418M . free .
3. Web site: Entrez Gene: DOC2A double C2-like domains, alpha.
4. Orita S, Naito A, Sakaguchi G, Maeda M, Igarashi H, Sasaki T, Takai Y . Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery . J. Biol. Chem. . 272 . 26 . 16081–4 . June 1997 . 9195900 . 10.1074/jbc.272.26.16081 . free .
5. Web site: Protein unc-13 homolog A. UniProt.