DOB-FLY explained

DOB-FLY is a recreational designer drug with psychedelic effects. It can be regarded as the alpha-methyl derivative of 2C-B-FLY or the partially saturated counterpart of bromo-dragonfly. Unlike bromo-dragonfly, DOB-FLY is only slightly more potent than DOB itself, with an active dose in humans of around 1 mg.^{[1] [2] [3] [4] [5] [6]}

See also

• 2C-B-BUTTERFLY
• 2C-B-DRAGONFLY
• 2C-E-FLY
• NBOMe-2C-B-FLY
• TFMFly
• Substituted benzofuran

Notes and References

1. Parker MA, Marona-Lewicka D, Lucaites VL, Nelson DL, Nichols DE . A novel (benzodifuranyl)aminoalkane with extremely potent activity at the 5-HT2A receptor . Journal of Medicinal Chemistry . 41 . 26 . 5148–9 . December 1998 . 9857084 . 10.1021/jm9803525 .
2. Feng Z, Mohapatra S, Klimko PG, Hellberg MR, May JA, Kelly C, Williams G, McLaughlin MA, Sharif NA . 6 . Novel benzodifuran analogs as potent 5-HT2A receptor agonists with ocular hypotensive activity . Bioorganic & Medicinal Chemistry Letters . 17 . 11 . 2998–3002 . June 2007 . 17419053 . 10.1016/j.bmcl.2007.03.073 .
3. Parker MA, Kurrasch DM, Nichols DE . The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands . Bioorganic & Medicinal Chemistry . 16 . 8 . 4661–9 . April 2008 . 18296055 . 10.1016/j.bmc.2008.02.033 . 2442558 .
4. Schultz DM, Prescher JA, Kidd S, Marona-Lewicka D, Nichols DE, Monte A . 'Hybrid' benzofuran-benzopyran congeners as rigid analogs of hallucinogenic phenethylamines . Bioorganic & Medicinal Chemistry . 16 . 11 . 6242–51 . June 2008 . 18467103 . 10.1016/j.bmc.2008.04.030 . 2601679 .
5. Zaitsu K, Katagi M, Kamata H, Nakanishi K, Shima N, Kamata T, Nishioka H, Miki A, Tatsuno M, Tsuchihashi H . 6 . Simultaneous analysis of six novel hallucinogenic (tetrahydrobenzodifuranyl) aminoalkanes (FLYs) and (benzodifuranyl) aminoalkanes (DragonFLYs) by GC-MS, LC-MS, and LC-MS-MS. . Forensic Toxicology . January 2010 . 28 . 1 . 9–18 . 10.1007/s11419-009-0083-0 . 24100422 .
6. Halberstadt AL, Chatha M, Stratford A, Grill M, Brandt SD . Comparison of the behavioral responses induced by phenylalkylamine hallucinogens and their tetrahydrobenzodifuran ("FLY") and benzodifuran ("DragonFLY") analogs . Neuropharmacology . 144 . 368–376 . January 2019 . 30385253 . 10.1016/j.neuropharm.2018.10.037 . 6863604 .