DNA polymerase III, delta subunit explained

DNA polymerase III, delta subunit
Organism:Escherichia coli
(str. K-12 substr. MG1655)
Taxid:511145
Symbol:holA
Entrezgene:947573
Refseqprotein:NP_415173.1
Uniprot:P28630
Ecnumber:2.7.7.7
Chromosome:genome
Entrezchromosome:NC_000913.2
Genloc Start:669641
Genloc End:670982
Symbol:DNA_pol3_delta
DNA polymerase III, delta subunit
Pfam:PF06144
Pfam Clan:CL0023
Interpro:IPR010372
Scop:1jql

In molecular biology, the δ (delta) subunit of DNA polymerase III is encoded by the holA gene in E. coli and other bacteria. Along with the γ, δ', χ, and ψ subunits that make up the core polymerase, and the β accessory proteins, the δ subunit is responsible for the high speed and processivity of polIII.[1] [2]

Notes and References

  1. Dong Z, Onrust R, Skangalis M, O'Donnell M . DNA polymerase III accessory proteins. I. holA and holB encoding delta and delta' . The Journal of Biological Chemistry . 268 . 16 . 11758–65 . June 1993 . 10.1016/S0021-9258(19)50264-2 . 8505303 . free .
  2. Carter JR, Franden MA, Aebersold R, McHenry CS . Molecular cloning, sequencing, and overexpression of the structural gene encoding the delta subunit of Escherichia coli DNA polymerase III holoenzyme . Journal of Bacteriology . 174 . 21 . 7013–25 . 1992 . 1400251 . 207382 . 10.1128/jb.174.21.7013-7025.1992 .