DNA ligase (NAD+) explained

DNA ligase (NAD+)
Ec Number:6.5.1.2
Cas Number:37259-52-2

DNA ligase (NAD+) (polydeoxyribonucleotide synthase (NAD+), polynucleotide ligase (NAD+), DNA repair enzyme, DNA joinase, polynucleotide synthetase (nicotinamide adenine dinucleotide), deoxyribonucleic-joining enzyme, deoxyribonucleic ligase, deoxyribonucleic repair enzyme, deoxyribonucleic joinase, DNA ligase, deoxyribonucleate ligase, polynucleotide ligase, deoxyribonucleic acid ligase, polynucleotide synthetase, deoxyribonucleic acid joinase, DNA-joining enzyme, polynucleotide ligase (nicotinamide adenine dinucleotide)) is an enzyme with systematic name poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming).[1] This enzyme catalyses the following chemical reaction

NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m

\rightleftharpoons

AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m

Catalyses the formation of a phosphodiester at the site of a single-strand break in duplex DNA.

See also

Notes and References

  1. Zimmerman SB, Little JW, Oshinsky CK, Gellert M . Enzymatic joining of DNA strands: a novel reaction of diphosphopyridine nucleotide . Proceedings of the National Academy of Sciences of the United States of America . 57 . 6 . 1841–8 . June 1967 . 4291949 . 224555 . 10.1073/pnas.57.6.1841 . 1967PNAS...57.1841Z . free .

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