DNAJA2 explained

DnaJ homolog subfamily A member 2 is a protein that in humans is encoded by the DNAJA2 gene.^{[1] [2] [3]}

The protein encoded by this gene shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of this protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding interacting proteins, HIRIPs, have been identified. HIRIP4 was isolated by virtue of its interaction with this protein; however, its exact function is not known. The sequence of HIRIP4 protein is highly homologous to the human DNJ3/CPR3, mouse Dj3 and rat Dj2 gene products.

Further reading

• Bonwaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Edwards MC, Liegeois N, Horecka J . Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells . Genetics . 147 . 3 . 1063–76 . 1998 . 10.1093/genetics/147.3.1063 . 9383053 . 1208234 . etal.
• Scanlan MJ, Gordan JD, Williamson B . Antigens recognized by autologous antibody in patients with renal-cell carcinoma . Int. J. Cancer . 83 . 4 . 456–64 . 1999 . 10508479 . 10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5 . etal. 21839750 .
• Diefenbach J, Kindl H . The membrane-bound DnaJ protein located at the cytosolic site of glyoxysomes specifically binds the cytosolic isoform 1 of Hsp70 but not other Hsp70 species . Eur. J. Biochem. . 267 . 3 . 746–54 . 2000 . 10651811 . 10.1046/j.1432-1327.2000.01053.x . free .
• Terada K, Mori M . Human DnaJ homologs dj2 and dj3, and bag-1 are positive cochaperones of hsc70 . J. Biol. Chem. . 275 . 32 . 24728–34 . 2000 . 10816573 . 10.1074/jbc.M002021200 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Willingham S, Outeiro TF, DeVit MJ . Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein . Science . 302 . 5651 . 1769–72 . 2003 . 14657499 . 10.1126/science.1090389 . 2003Sci...302.1769W . 43221047 . etal.
• Kho Y, Kim SC, Jiang C . A tagging-via-substrate technology for detection and proteomics of farnesylated proteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 34 . 12479–84 . 2004 . 15308774 . 10.1073/pnas.0403413101 . 515085 . 2004PNAS..10112479K . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Kimura K, Wakamatsu A, Suzuki Y . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . etal.
• Olsen JV, Blagoev B, Gnad F . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . etal. free .

Notes and References

1. Lorain S, Quivy JP, Monier-Gavelle F, Scamps C, Lecluse Y, Almouzni G, Lipinski M . Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA . Mol Cell Biol . 18 . 9 . 5546–56 . Sep 1998 . 9710638 . 109139 . 10.1128/MCB.18.9.5546.
2. Ohtsuka K, Hata M . Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature . Cell Stress & Chaperones . 5 . 2 . 98–112 . Jan 2001 . 10.1379/1466-1268(2000)005<0098:mhdhco>2.0.co;2 . 2024-03-06 . 11147971 . 312896 . 1466-1268 .
3. Web site: Entrez Gene: DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2.