DNAJA1 explained

DnaJ homolog subfamily A member 1 is a protein that in humans is encoded by the DNAJA1 gene.^{[1] [2] [3]}

Interactions

DNAJA1 has been shown to interact with PTTG1.^[4]

Further reading

• Oh S, Iwahori A, Kato S . Human cDNA encoding DnaJ protein homologue. . Biochim. Biophys. Acta . 1174 . 1 . 114–6 . 1993 . 8334161 . 10.1016/0167-4781(93)90104-l.
• Kanazawa M, Terada K, Kato S, Mori M . HSDJ, a human homolog of DnaJ, is farnesylated and is involved in protein import into mitochondria. . J. Biochem. . 121 . 5 . 890–5 . 1997 . 9192730 . 10.1093/oxfordjournals.jbchem.a021670.
• Davis AR, Alevy YG, Chellaiah A . Characterization of HDJ-2, a human 40 kD heat shock protein. . Int. J. Biochem. Cell Biol. . 30 . 11 . 1203–21 . 1998 . 9839446 . 10.1016/S1357-2725(98)00091-0 . etal.
• Pei L . Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells. . J. Biol. Chem. . 274 . 5 . 3151–8 . 1999 . 9915854 . 10.1074/jbc.274.5.3151 . free .
• Meacham GC, Lu Z, King S . The Hdj-2/Hsc70 chaperone pair facilitates early steps in CFTR biogenesis. . EMBO J. . 18 . 6 . 1492–505 . 1999 . 10075921 . 10.1093/emboj/18.6.1492 . 1171238 . etal.
• Terada K, Mori M . Human DnaJ homologs dj2 and dj3, and bag-1 are positive cochaperones of hsc70. . J. Biol. Chem. . 275 . 32 . 24728–34 . 2000 . 10816573 . 10.1074/jbc.M002021200 . free .
• Jana NR, Tanaka M, Wang G, Nukina N . Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity. . Hum. Mol. Genet. . 9 . 13 . 2009–18 . 2000 . 10942430 . 10.1093/hmg/9.13.2009 . free .
• Bao YP, Cook LJ, O'Donovan D . Mammalian, yeast, bacterial, and chemical chaperones reduce aggregate formation and death in a cell model of oculopharyngeal muscular dystrophy. . J. Biol. Chem. . 277 . 14 . 12263–9 . 2002 . 11796717 . 10.1074/jbc.M109633200 . etal. free .
• Hernández MP, Chadli A, Toft DO . HSP40 binding is the first step in the HSP90 chaperoning pathway for the progesterone receptor. . J. Biol. Chem. . 277 . 14 . 11873–81 . 2002 . 11809754 . 10.1074/jbc.M111445200 . free .
• Imai Y, Soda M, Hatakeyama S . CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity. . Mol. Cell . 10 . 1 . 55–67 . 2002 . 12150907 . 10.1016/S1097-2765(02)00583-X . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal. 2002PNAS...9916899M . free .
• Hanai R, Mashima K . Characterization of two isoforms of a human DnaJ homologue, HSJ2. . Mol. Biol. Rep. . 30 . 3 . 149–53 . 2004 . 12974469 . 10.1023/A:1024916223616 . 24105834 .
• Lehner B, Semple JI, Brown SE . Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. . Genomics . 83 . 1 . 153–67 . 2004 . 14667819 . 10.1016/S0888-7543(03)00235-0 . etal.
• Bouwmeester T, Bauch A, Ruffner H . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. . Nat. Cell Biol. . 6 . 2 . 97–105 . 2004 . 14743216 . 10.1038/ncb1086 . 11683986 . etal.
• Marschang P, Brich J, Weeber EJ . Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1. . Mol. Cell. Biol. . 24 . 9 . 3782–93 . 2004 . 15082773 . 10.1128/MCB.24.9.3782-3793.2004 . 387731 . etal.
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Rush J, Moritz A, Lee KA . Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. . Nat. Biotechnol. . 23 . 1 . 94–101 . 2005 . 15592455 . 10.1038/nbt1046 . 7200157 . etal.
• Hu Y, Zhou Z, Huang X . Expression of a novel DnaJA1 alternative splicing in human testis and sperm. . Int. J. Androl. . 27 . 6 . 343–9 . 2005 . 15595953 . 10.1111/j.1365-2605.2004.00492.x . etal. free .

Notes and References

1. Chellaiah A, Davis A, Mohanakumar T . Cloning of a unique human homologue of the Escherichia coli DNAJ heat shock protein . Biochim Biophys Acta . 1174 . 1 . 111–3 . August 1993 . 8334160 . 10.1016/0167-4781(93)90103-k.
2. Ohtsuka K, Hata M . Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature . Cell Stress & Chaperones . 5 . 2 . 98–112 . January 2001 . 10.1379/1466-1268(2000)005<0098:mhdhco>2.0.co;2 . 2024-03-28 . 11147971 . 312896 .
3. Web site: Entrez Gene: DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1.
4. 10.1074/jbc.274.5.3151 . Pei . L . January 1999 . Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells . J. Biol. Chem. . 274 . 5 . 3151–8 . UNITED STATES. 0021-9258. 9915854 . free .