DNAH9 explained

Dynein heavy chain 9, axonemal is a protein that in humans is encoded by the DNAH9 gene.^{[1] [2] [3]}

This gene encodes the heavy chain subunit of axonemal dynein, a large multi-subunit molecular motor. Axonemal dynein attaches to microtubules and hydrolyzes ATP to mediate the movement of cilia and flagella. The gene expresses at least two transcript variants; additional variants have been described, but their full length nature has not been determined.

Further reading

• Milisav I, Jones MH, Affara NA . Characterization of a novel human dynein-related gene that is specifically expressed in testis . Mamm. Genome . 7 . 9 . 667–72 . 1996 . 8703119 . 10.1007/s003359900202 . 30004271 .
• Nagase T . Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Res. . 4 . 2 . 141–50 . 1997 . 9205841 . 10.1093/dnares/4.2.141 . Ishikawa K . Nakajima D . 3 . Ohira . M . Seki . N . Miyajima . N . Tanaka . A . Kotani . H . Nomura . N . free .
• Bartoloni L . Assignment of the human dynein heavy chain gene DNAH17L to human chromosome 17p12 by in situ hybridization and radiation hybrid mapping . Cytogenet. Cell Genet. . 84 . 3–4 . 188–9 . 1999 . 10393427 . 10.1159/000015254 . Blouin J . Sainsbury AJ . 3 . Gos . A. . Morris . M.A. . Affara . N.A. . Delozier-Blanchet . C.D. . Antonarakis . S.E. . 1495548 .
• Reed W . Characterization of an axonemal dynein heavy chain expressed early in airway epithelial ciliogenesis . Am. J. Respir. Cell Mol. Biol. . 23 . 6 . 734–41 . 2001 . 11104725 . 10.1165/ajrcmb.23.6.4045. Carson JL . Moats-Staats BM . 3 . Lucier . T . Hu . P . Brighton . L . Gambling . TM . Huang . CH . Leigh . MW . 10.1.1.321.874 .
• Maiti AK . Identification, tissue specific expression, and chromosomal localisation of several human dynein heavy chain genes . Eur. J. Hum. Genet. . 8 . 12 . 923–32 . 2001 . 11175280 . 10.1038/sj.ejhg.5200555 . Mattéi MG . Jorissen M . 3 . Volz . Armin . Zeigler . Andreas . Bouvagnet . Patrice . free.
• Carson JL . Axonemal dynein expression in human fetal tracheal epithelium . Am. J. Physiol. Lung Cell Mol. Physiol. . 282 . 3 . L421–30 . 2002 . 11839535 . 10.1152/ajplung.00147.2001 . Reed W . Lucier T . 3 . Brighton . L . Gambling . TM . Huang . CH . Collier . AM . 23922796 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Horváth J . Identification and analysis of axonemal dynein light chain 1 in primary ciliary dyskinesia patients . Am. J. Respir. Cell Mol. Biol. . 33 . 1 . 41–7 . 2005 . 15845866 . 10.1165/rcmb.2004-0335OC . Fliegauf M . Olbrich H . 3 . Kispert . A . King . SM . Mitchison . H . Zariwala . MA . Knowles . MR . Sudbrak . R . 19776274 .

Notes and References

1. Vaughan KT, Mikami A, Paschal BM, Holzbaur EL, Hughes SM, Echeverri CJ, Moore KJ, Gilbert DJ, Copeland NG, Jenkins NA, Vallee RB . Multiple mouse chromosomal loci for dynein-based motility . Genomics . 36 . 1 . 29–38 . Feb 1997 . 8812413 . 10.1006/geno.1996.0422 .
2. Bartoloni L, Blouin JL, Maiti AK, Sainsbury A, Rossier C, Gehrig C, She JX, Marron MP, Lander ES, Meeks M, Chung E, Armengot M, Jorissen M, Scott HS, Delozier-Blanchet CD, Gardiner RM, Antonarakis SE . Axonemal beta heavy chain dynein DNAH9: cDNA sequence, genomic structure, and investigation of its role in primary ciliary dyskinesia . Genomics . 72 . 1 . 21–33 . Mar 2001 . 11247663 . 10.1006/geno.2000.6462 . 2123/16163 . free .
3. Web site: Entrez Gene: DNAH9 dynein, axonemal, heavy chain 9.