DNA2L explained
DNA2-like helicase is an enzyme that in humans is encoded by the DNA2 gene.[1] [2] [3] Dna2, a homolog of DNA2KL present in budding yeast, possesses both helicase and nuclease activity, with which it helps catalyze early steps in homologous recombination.[4]
Further reading
- Masuda-Sasa T, Imamura O, Campbell JL . Biochemical analysis of human Dna2 . Nucleic Acids Res. . 34 . 6 . 1865–75 . 2006 . 16595800 . 10.1093/nar/gkl070 . 1428797 .
- Kim JH, Kim HD, Ryu GH . Isolation of human Dna2 endonuclease and characterization of its enzymatic properties . Nucleic Acids Res. . 34 . 6 . 1854–64 . 2006 . 16595799 . 10.1093/nar/gkl102 . 1428795 . etal.
- Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
- Deloukas P, Earthrowl ME, Grafham DV . The DNA sequence and comparative analysis of human chromosome 10 . Nature . 429 . 6990 . 375–81 . 2004 . 15164054 . 10.1038/nature02462 . 2004Natur.429..375D . etal. free .
- Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
- Nagase T, Miyajima N, Tanaka A . Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1 . DNA Res. . 2 . 1 . 37–43 . 1995 . 7788527 . 10.1093/dnares/2.1.37 . etal. free .
Notes and References
- Eki T, Okumura K, Shiratori A, Abe M, Nogami M, Taguchi H, Shibata T, Murakami Y, Hanaoka F . Assignment of the closest human homologue (DNA2L:KIAA0083) of the yeast Dna2 helicase gene to chromosome band 10q21.3-q22.1 . Genomics . 37 . 3 . 408–10 . Mar 1997 . 8938459 . 10.1006/geno.1996.0581 .
- Masuda-Sasa T, Polaczek P, Campbell JL . Single strand annealing and ATP-independent strand exchange activities of yeast and human DNA2: possible role in Okazaki fragment maturation . J Biol Chem . 281 . 50 . 38555–64 . Dec 2006 . 17032657 . 10.1074/jbc.M604925200 . free .
- Web site: Entrez Gene: DNA2L DNA2 DNA replication helicase 2-like (yeast).
- Nucleases and helicases take center stage in homologous recombination . Trends in Biochemical Sciences . Mimitou . EP . Symington . LS . May 2009 . 34 . 5 . 264–272 . 10.1016/j.tibs.2009.01.010 . 19375328.
