DNA-dependent ATPase explained

DNA-dependent ATPase, abbreviated Dda and also known as Dda helicase and Dda DNA helicase, is the 439-amino acid 49,897-atomic mass unit protein coded by the Dda gene of the bacteriophage T4 phage, a virus that infects enterobacteria.

Biochemistry

Dda is a molecular motor, specifically a helicase that moves in the 5' end to 3' direction along a nucleic acid phosphodiester backbone, separating two annealed nucleic acid strands, using the free energy released by the hydrolysis of adenosine triphosphate. The National Center for Biotechnology Information (NCBI) Reference Sequence accession number is NP_049632.

Molecular biology

Dda is involved in the initiation of T4 DNA replication and DNA recombination.

Genetics

The Dda gene is 31,219 base pair long. The GenBank accession number is AAD42555. The coding strand (see also: sense strand) begins in base number 9,410 and ends in base number 10,729.^{[1] [2]}

Cellular biology

Dda is toxic to cells at elevated levels.

See also

• Enzymes
• Motor proteins
• Transcription (genetics)

References

1. Web site: Enterobacteria phage T4, complete genome. 13 August 2018.
2. Web site: Dda - ATP-dependent DNA helicase dda - Enterobacteria phage T4 - dda gene & protein.

External links

• National Center for Biotechnology – Biomedical and genomic information via the National Library of Medicine (NLM) at the National Institutes of Health (NIH).