DNA-3-methyladenine glycosylase I explained

DNA-3-methyladenine glycosylase I
Ec Number:3.2.2.20
Cas Number:89287-37-6

DNA-3-methyladenine glycosylase I (deoxyribonucleate 3-methyladenine glycosidase I, 3-methyladenine DNA glycosylase I, DNA-3-methyladenine glycosidase I) is an enzyme with systematic name alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine).[1] [2] [3] This enzyme catalyses the following chemical reaction

Hydrolysis of alkylated DNA, releasing 3-methyladenine

This enzyme is involved in the removal of alkylated bases from DNA in Escherichia coli.

Notes and References

  1. Evensen G, Seeberg E . Adaptation to alkylation resistance involves the induction of a DNA glycosylase . Nature . 296 . 5859 . 773–5 . April 1982 . 7040984 . 10.1038/296773a0 . 1982Natur.296..773E . 4318955 .
  2. Karran P, Hjelmgren T, Lindahl T . Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents . Nature . 296 . 5859 . 770–3 . April 1982 . 7040983 . 10.1038/296770a0 . 1982Natur.296..770K . 4367726 .
  3. Thomas L, Yang CH, Goldthwait DA . Two DNA glycosylases in Escherichia coli which release primarily 3-methyladenine . Biochemistry . 21 . 6 . 1162–9 . March 1982 . 7041972 . 10.1021/bi00535a009 .

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