DMWD (gene) explained

Dystrophia myotonica WD repeat-containing protein is a protein that in humans is encoded by the DMWD gene.^{[1] [2]}

Further reading

• Groenen P, Wieringa B . Expanding complexity in myotonic dystrophy. . BioEssays . 20 . 11 . 901–12 . 1999 . 9872056 . 10.1002/(SICI)1521-1878(199811)20:11<901::AID-BIES5>3.0.CO;2-0 . 24160357 .
• Wansink DG, Wieringa B . Transgenic mouse models for myotonic dystrophy type 1 (DM1). . Cytogenet. Genome Res. . 100 . 1–4 . 230–42 . 2004 . 14526185 . 10.1159/000072859 . 9981696 .
• Jansen G, Bächner D, Coerwinkel M . Structural organization and developmental expression pattern of the mouse WD-repeat gene DMR-N9 immediately upstream of the myotonic dystrophy locus . Hum. Mol. Genet. . 4 . 5 . 843–52 . 1995 . 7633444 . 10.1093/hmg/4.5.843 . etal. 2066/21198 . free .
• Shaw DJ, McCurrach M, Rundle SA . Genomic organization and transcriptional units at the myotonic dystrophy locus . Genomics . 18 . 3 . 673–9 . 1994 . 7905855 . 10.1016/S0888-7543(05)80372-6 . etal.
• Mahadevan MS, Amemiya C, Jansen G . Structure and genomic sequence of the myotonic dystrophy (DM kinase) gene . Hum. Mol. Genet. . 2 . 3 . 299–304 . 1993 . 8499920 . 10.1093/hmg/2.3.299 . etal.
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Alwazzan M, Newman E, Hamshere MG, Brook JD . Myotonic dystrophy is associated with a reduced level of RNA from the DMWD allele adjacent to the expanded repeat . Hum. Mol. Genet. . 8 . 8 . 1491–7 . 1999 . 10400997 . 10.1093/hmg/8.8.1491 . free .
• Eriksson M, Hedberg B, Carey N, Ansved T . Decreased DMPK transcript levels in myotonic dystrophy 1 type IIA muscle fibers . Biochem. Biophys. Res. Commun. . 286 . 5 . 1177–82 . 2001 . 11527424 . 10.1006/bbrc.2001.5516 .
• Frisch R, Singleton KR, Moses PA . Effect of triplet repeat expansion on chromatin structure and expression of DMPK and neighboring genes, SIX5 and DMWD, in myotonic dystrophy . Mol. Genet. Metab. . 74 . 1–2 . 281–91 . 2001 . 11592825 . 10.1006/mgme.2001.3229 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Grimwood J, Gordon LA, Olsen A . The DNA sequence and biology of human chromosome 19 . Nature . 428 . 6982 . 529–35 . 2004 . 15057824 . 10.1038/nature02399 . 2004Natur.428..529G . etal. free .
• Beausoleil SA, Jedrychowski M, Schwartz D . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . 2004PNAS..10112130B . etal. free .

Notes and References

1. Jansen G, Mahadevan M, Amemiya C, Wormskamp N, Segers B, Hendriks W, O'Hoy K, Baird S, Sabourin L, Lennon G . Characterization of the myotonic dystrophy region predicts multiple protein isoform-encoding mRNAs . Nat Genet . 1 . 4 . 261–6 . Jun 1993 . 1302022 . 10.1038/ng0792-261 . 26072532 . etal.
2. Web site: Entrez Gene: DMWD dystrophia myotonica, WD repeat containing.