DMCM explained

DMCM (methyl 6,7-dimethoxy-4-ethyl-β-carboline-3-carboxylate) is a drug from the β-carboline family that induces anxiety and convulsions by acting as a negative allosteric modulator of GABA_A receptors — functionally opposite to benzodiazepines and related drugs which are positive allosteric modulators — and is used in scientific research for these properties to test new anxiolytic and anticonvulsant medications, respectively.^[1] ^[2] ^[3] ^[4] It has also been shown to produce analgesic effects in animals, which is thought to be the drug's induced panic reducing the perception of pain.^[5]

Notes and References

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De Sarro . G . Chimirri . A . McKernan . R . Quirk . K . Giusti . P . De Sarro . A . Anticonvulsant activity of azirino[1,2-''d''][1,4]benzodiazepines and related 1,4-benzodiazepines in mice . Pharmacology Biochemistry and Behavior . 58 . 1 . 281–9 . 1997 . 9264104 . 10.1016/S0091-3057(96)00565-5. 24492818 .
Leppä . E . Vekovischeva . OY . Lindén . AM . Wulff . P . Oberto . A . Wisden . W . Korpi . ER . Agonistic effects of the β-carboline DMCM revealed in GABA_A receptor γ2 subunit F77I point-mutated mice . Neuropharmacology . 48 . 4 . 469–78 . 2005 . 15755475 . 10.1016/j.neuropharm.2004.11.007 . 54340687 .
Sieve . AN . King . TE . Ferguson . AR . Grau . JW . Meagher . MW . Pain and negative affect: evidence the inverse benzodiazepine agonist DMCM inhibits pain and learning in rats . Psychopharmacology . 153 . 2 . 180–90 . 2001 . 11205417 . 10.1007/s002130000535. 2591731 .