DLX6 explained

Homeobox protein DLX-6 is a protein that in humans is encoded by the DLX6 gene.^{[1] [2]}

This gene encodes a member of a homeobox transcription factor gene family similar to the Drosophila distal-less gene. This family has at least six members that encode proteins with roles in forebrain and craniofacial development. This gene is in a tail-to-tail configuration with another member of the family, DLX5, on the long arm of chromosome 7.

Further reading

• Crackower MA, Scherer SW, Rommens JM . Characterization of the split hand/split foot malformation locus SHFM1 at 7q21.3-q22.1 and analysis of a candidate gene for its expression during limb development. . Hum. Mol. Genet. . 5 . 5 . 571–9 . 1997 . 8733122 . 10.1093/hmg/5.5.571 . etal. free .
• Charité J, McFadden DG, Merlo G . Role of Dlx6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer. . Genes Dev. . 15 . 22 . 3039–49 . 2001 . 11711438 . 10.1101/gad.931701 . 312822 . etal.
• Depew MJ, Lufkin T, Rubenstein JL . Specification of jaw subdivisions by Dlx genes. . Science . 298 . 5592 . 381–5 . 2002 . 12193642 . 10.1126/science.1075703 . 10274300 . free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Nabi R, Zhong H, Serajee FJ, Huq AH . No association between single nucleotide polymorphisms in DLX6 and Piccolo genes at 7q21-q22 and autism. . Am. J. Med. Genet. B Neuropsychiatr. Genet. . 119 . 1 . 98–101 . 2004 . 12707945 . 10.1002/ajmg.b.10012 . 39985829 . free .
• Hillier LW, Fulton RS, Fulton LA . The DNA sequence of human chromosome 7. . Nature . 424 . 6945 . 157–64 . 2003 . 12853948 . 10.1038/nature01782 . 2003Natur.424..157H . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Schüle B, Li HH, Fisch-Kohl C . DLX5 and DLX6 expression is biallelic and not modulated by MeCP2 deficiency. . Am. J. Hum. Genet. . 81 . 3 . 492–506 . 2007 . 17701895 . 10.1086/520063 . 1950824 . etal.

Notes and References

1. Simeone A, Acampora D, Pannese M, D'Esposito M, Stornaiuolo A, Gulisano M, Mallamaci A, Kastury K, Druck T, Huebner K . Cloning and characterization of two members of the vertebrate Dlx gene family . Proc Natl Acad Sci U S A . 91 . 6 . 2250–4 . Apr 1994 . 7907794 . 43348 . 10.1073/pnas.91.6.2250 . 1994PNAS...91.2250S . etal. free .
2. Web site: Entrez Gene: DLX6 distal-less homeobox 6.