DLGAP4 explained

Disks large-associated protein 4 (DAP-4) also known as SAP90/PSD-95-associated protein 4 (SAPAP-4) is a protein that in humans is encoded by the DLGAP4 gene.^{[1] [2]}

Function

DAP-4 is a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. It is a signaling molecule that can interact with potassium channels and receptors, as well as other signaling molecules. DAP-4 can interact with PSD-95 through its guanylate kinase domain and may be involved in clustering PSD-95 in the postsynaptic density region. The encoded protein is one of at least four similar proteins that have been found. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Further reading

• Kim JH, Liao D, Lau LF, Huganir RL . SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family . Neuron . 20 . 4 . 683–91 . 1998 . 9581761 . 10.1016/S0896-6273(00)81008-9 . 12247592 . free .
• Chen HJ, Rojas-Soto M, Oguni A, Kennedy MB . A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II . Neuron . 20 . 5 . 895–904 . 1998 . 9620694 . 10.1016/S0896-6273(00)80471-7 . 14655729 . free .
• Nagase T . Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 6 . 1 . 63–70 . 1999 . 10231032 . 10.1093/dnares/6.1.63 . vanc. Ishikawa K . Suyama M . 3 . Kikuno . R . Hirosawa . M . Miyajima . N . Tanaka . A . Kotani . H . Nomura . N . free .
• Kawabe H . nArgBP2, a novel neural member of ponsin/ArgBP2/vinexin family that interacts with synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP) . J. Biol. Chem. . 274 . 43 . 30914–8 . 1999 . 10521485 . 10.1074/jbc.274.43.30914 . vanc. Hata Y . Takeuchi M . 3 . Ide . N . Mizoguchi . A . Takai . Y . free .
• Husi H . Proteomic analysis of NMDA receptor-adhesion protein signaling complexes . Nat. Neurosci. . 3 . 7 . 661–9 . 2000 . 10862698 . 10.1038/76615 . vanc. Ward MA . Choudhary JS . 3 . Choudhary . Jyoti S. . Blackstock . Walter P. . 1842/742 . 14392630 . free .
• Pei L, Teves RL, Wallace MC, Gurd JW . Transient cerebral ischemia increases tyrosine phosphorylation of the synaptic RAS-GTPase activating protein, SynGAP . J. Cereb. Blood Flow Metab. . 21 . 8 . 955–63 . 2001 . 11487731 . 10.1097/00004647-200108000-00008 . free .
• Deloukas P . The DNA sequence and comparative analysis of human chromosome 20 . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . vanc. Matthews LH . Ashurst J . 3 . Burton . J. . Gilbert . J. G. R. . Jones . M. . Stavrides . G. . Almeida . J. P. . Babbage . A. K. . 2001Natur.414..865D . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Riefler GM . Exocyst complex subunit sec8 binds to postsynaptic density protein-95 (PSD-95): a novel interaction regulated by cypin (cytosolic PSD-95 interactor) . Biochem. J. . 373 . Pt 1 . 49–55 . 2003 . 12675619 . 10.1042/BJ20021838 . 1223477 . vanc. Balasingam G . Lucas KG . 3 . Wang . Sheng . Hsu . Shu-Chan . Firestein . Bonnie L. .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Song B, Yan XB, Zhang GY . PSD-95 promotes CaMKII-catalyzed serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP after transient brain ischemia in rat hippocampus . Brain Res. . 1005 . 1–2 . 44–50 . 2004 . 15044063 . 10.1016/j.brainres.2004.01.032 . 33854259 .
• Brandenberger R . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation . Nat. Biotechnol. . 22 . 6 . 707–16 . 2005 . 15146197 . 10.1038/nbt971 . vanc. Wei H . Zhang S . 3 . Lei . Shirley . Murage . Jaji . Fisk . Gregory J . Li . Yan . Xu . Chunhui . Fang . Rixun . 27764390 .
• Kimura K . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . vanc. Wakamatsu A . Suzuki Y . 3 . Ota . T . Nishikawa . T . Yamashita . R . Yamamoto . J . Sekine . M . Tsuritani . K .

Notes and References

1. Takeuchi M, Hata Y, Hirao K, Toyoda A, Irie M, Takai Y . SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density . J Biol Chem . 272 . 18 . 11943–51 . Jun 1997 . 9115257 . 10.1074/jbc.272.18.11943 . free .
2. Web site: Entrez Gene: DLGAP4 discs, large (Drosophila) homolog-associated protein 4.