DLG2 explained

Disks large homolog 2 (DLG2) also known as channel-associated protein of synapse-110 (chapsyn-110) or postsynaptic density protein 93 (PSD-93) is a protein that in humans is encoded by the DLG2 gene.^{[1] [2]}

Function

Chapsyn-110/PSD-93 a member of the membrane-associated guanylate kinase (MAGUK) family. The protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Alternatively spliced transcript variants encoding distinct isoforms have been described but their full-length nature has yet to be completely determined.^[3]

Interactions

DLG2 has been shown to interact with GRIN2B,^{[4] [5]} KCNJ12.^[6]

Further reading

• Kim E, Niethammer M, Rothschild A, Jan YN, Sheng M . Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases. . Nature . 378 . 6552 . 85–8 . 1995 . 7477295 . 10.1038/378085a0 . 1995Natur.378...85K . 4362906 .
• Brenman JE, Chao DS, Gee SH, McGee AW, Craven SE, Santillano DR, Wu Z, Huang F, Xia H, Peters MF, Froehner SC, Bredt DS . Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains. . Cell . 84 . 5 . 757–67 . 1996 . 8625413 . 10.1016/S0092-8674(00)81053-3 . 15834673 . free .
• Hsueh YP, Kim E, Sheng M . Disulfide-linked head-to-head multimerization in the mechanism of ion channel clustering by PSD-95. . Neuron . 18 . 5 . 803–14 . 1997 . 9182804 . 10.1016/S0896-6273(00)80319-0 . 18331544 . free .
• Niethammer M, Valtschanoff JG, Kapoor TM, Allison DW, Weinberg RJ, Craig AM, Sheng M . CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90. . Neuron . 20 . 4 . 693–707 . 1998 . 9581762 . 10.1016/S0896-6273(00)81009-0 . 16068361 . free .
• Leonard AS, Davare MA, Horne MC, Garner CC, Hell JW . SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit. . J. Biol. Chem. . 273 . 31 . 19518–24 . 1998 . 9677374 . 10.1074/jbc.273.31.19518 . free .
• Butz S, Okamoto M, Südhof TC . A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. . Cell . 94 . 6 . 773–82 . 1998 . 9753324 . 10.1016/S0092-8674(00)81736-5 . 12465062 . free .
• Brenman JE, Topinka JR, Cooper EC, McGee AW, Rosen J, Milroy T, Ralston HJ, Bredt DS . Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A. . J. Neurosci. . 18 . 21 . 8805–13 . 1998 . 9786987 . 10.1523/JNEUROSCI.18-21-08805.1998. 6793550 . free .
• Craven SE, El-Husseini AE, Bredt DS . Synaptic targeting of the postsynaptic density protein PSD-95 mediated by lipid and protein motifs. . Neuron . 22 . 3 . 497–509 . 1999 . 10197530 . 10.1016/S0896-6273(00)80705-9 . free .
• Sans N, Petralia RS, Wang YX, Blahos J, Hell JW, Wenthold RJ . A developmental change in NMDA receptor-associated proteins at hippocampal synapses. . J. Neurosci. . 20 . 3 . 1260–71 . 2000 . 10648730 . 10.1523/JNEUROSCI.20-03-01260.2000. free . 6774158 .
• Garcia RA, Vasudevan K, Buonanno A . The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses. . Proc. Natl. Acad. Sci. U.S.A. . 97 . 7 . 3596–601 . 2000 . 10725395 . 16285 . 10.1073/pnas.070042497 . free .
• Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG . Proteomic analysis of NMDA receptor-adhesion protein signaling complexes. . Nat. Neurosci. . 3 . 7 . 661–9 . 2000 . 10862698 . 10.1038/76615 . 1842/742 . 14392630 . free .
• Firestein BL, Craven SE, Bredt DS . Postsynaptic targeting of MAGUKs mediated by distinct N-terminal domains. . NeuroReport . 11 . 16 . 3479–84 . 2001 . 11095503 . 10.1097/00001756-200011090-00016 . 19718975 .
• Haraguchi K, Satoh K, Yanai H, Hamada F, Kawabuchi M, Akiyama T . The hDLG-associated protein DAP interacts with dynein light chain and neuronal nitric oxide synthase. . Genes Cells . 5 . 11 . 905–911 . 2001 . 11122378 . 10.1046/j.1365-2443.2000.00374.x . 37107139 . free .
• DeMarco SJ, Strehler EE . Plasma membrane Ca2+-atpase isoforms 2b and 4b interact promiscuously and selectively with members of the membrane-associated guanylate kinase family of PDZ (PSD95/Dlg/ZO-1) domain-containing proteins. . J. Biol. Chem. . 276 . 24 . 21594–600 . 2001 . 11274188 . 10.1074/jbc.M101448200 . free.
• Russwurm M, Wittau N, Koesling D . Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes. . J. Biol. Chem. . 276 . 48 . 44647–52 . 2002 . 11572861 . 10.1074/jbc.M105587200 . free .
• Book: Weitzdoerfer R, Dierssen M, Fountoulakis M, Lubec G . Fetal life in Down Syndrome starts with normal neuronal density but impaired dendritic spines and synaptosomal structure . Protein Expression in Down Syndrome Brain . Journal of Neural Transmission. Supplementum . 61 . 59–70 . 2002 . 11771761 . 10.1007/978-3-7091-6262-0_5. 978-3-211-83704-7 .

Notes and References

1. Kim E, Cho KO, Rothschild A, Sheng M . Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins . Neuron . 17 . 1 . 103–13 . December 1996 . 8755482 . 10.1016/S0896-6273(00)80284-6 . 14852857 . free .
2. Stathakis DG, Lee D, Bryant PJ . Fine-scale physical map of the 11q21 region surrounding the human DLG2 locus, the gene encoding Chapsyn-110 . Genomics . 54 . 1 . 186–8 . January 1999 . 9806853 . 10.1006/geno.1998.5527 .
3. Web site: Entrez Gene: DLG2 discs, large homolog 2, chapsyn-110 (Drosophila).
4. Inanobe A, Fujita A, Ito M, Tomoike H, Inageda K, Kurachi Y . Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses . Am. J. Physiol., Cell Physiol. . 282 . 6 . C1396-403 . June 2002 . 11997254 . 10.1152/ajpcell.00615.2001 .
5. Irie M, Hata Y, Takeuchi M, Ichtchenko K, Toyoda A, Hirao K, Takai Y, Rosahl TW, Südhof TC . Binding of neuroligins to PSD-95 . Science . 277 . 5331 . 1511–5 . September 1997 . 9278515 . 10.1126/science.277.5331.1511 .
6. Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA . Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins . J. Biol. Chem. . 279 . 21 . 22331–46 . May 2004 . 15024025 . 10.1074/jbc.M400285200 . free .