Tesetaxel Explained

Tesetaxel is an orally administered taxane being investigated as a chemotherapy agent for various types of cancer, including breast cancer, gastric cancer,^[1] colorectal cancer, and other solid tumors. It differs from other members of the taxane class (e.g. paclitaxel or docetaxel) in that it is administered orally, not intravenously.^[2]

Notes and References

1. Evans T, Dobrila R, Berardi R, Sumpter KA, Wall LR, Oyama R, Anthoney DA . A phase II study of DJ-927 as second-line therapy in patients (pts) with advanced gastric cancer (GC) who have failed a 5-FU non taxane based regimen. Journal of Clinical Oncology. June 2006. 24. 18_suppl. 4081. 10.1200/jco.2006.24.18_suppl.4081.
2. Shionoya M, Jimbo T, Kitagawa M, Soga T, Tohgo A . DJ-927, a novel oral taxane, overcomes P-glycoprotein-mediated multidrug resistance in vitro and in vivo . Cancer Science . 94 . 5 . 459–66 . May 2003 . 12824894. 10.1111/j.1349-7006.2003.tb01465.x . free . 11160250 .