DIDO1 explained

Death-inducer obliterator 1 is a protein that in humans is encoded by the DIDO1 gene.^{[1] [2]}

Function

Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms.

Further reading

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• Nagase T, Ishikawa K, Nakajima D . Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. . DNA Res. . 4 . 2 . 141–50 . 1997 . 9205841 . 10.1093/dnares/4.2.141 . etal. free .
• Deloukas P, Matthews LH, Ashurst J . The DNA sequence and comparative analysis of human chromosome 20. . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . 2001Natur.414..865D . etal. free .
• Gomes I, Sharma TT, Edassery S . Novel transcription factors in human CD34 antigen-positive hematopoietic cells. . Blood . 100 . 1 . 107–19 . 2002 . 12070015 . 10.1182/blood.V100.1.107 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Brandenberger R, Wei H, Zhang S . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. . Nat. Biotechnol. . 22 . 6 . 707–16 . 2005 . 15146197 . 10.1038/nbt971 . 27764390 . etal.
• Fu GK, Wang JT, Yang J . Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. . Genomics . 84 . 1 . 205–10 . 2005 . 15203218 . 10.1016/j.ygeno.2004.01.011 . etal.
• Beausoleil SA, Jedrychowski M, Schwartz D . Large-scale characterization of HeLa cell nuclear phosphoproteins. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . 2004PNAS..10112130B . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Fütterer A, Campanero MR, Leonardo E . Dido gene expression alterations are implicated in the induction of hematological myeloid neoplasms. . J. Clin. Invest. . 115 . 9 . 2351–62 . 2005 . 16127461 . 10.1172/JCI24177 . 1190370 . etal.
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Beausoleil SA, Villén J, Gerber SA . A probability-based approach for high-throughput protein phosphorylation analysis and site localization. . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 . etal.
• Olsen JV, Blagoev B, Gnad F . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . etal. free .
• Trachana V, van Wely KH, Guerrero AA . Dido disruption leads to centrosome amplification and mitotic checkpoint defects compromising chromosome stability. . Proc. Natl. Acad. Sci. U.S.A. . 104 . 8 . 2691–6 . 2007 . 17299043 . 10.1073/pnas.0611132104 . 1815243 . 2007PNAS..104.2691T . etal. free .

Notes and References

1. Garcia-Domingo D, Leonardo E, Grandien A, Martinez P, Albar JP, Izpisua-Belmonte JC, Martinez-A C . DIO-1 is a gene involved in onset of apoptosis in vitro, whose misexpression disrupts limb development . Proc Natl Acad Sci U S A . 96 . 14 . 7992–7 . Aug 1999 . 10393935 . 22175 . 10.1073/pnas.96.14.7992 . 1999PNAS...96.7992G . free .
2. Web site: Entrez Gene: DIDO1 death inducer-obliterator 1.