DHX32 explained

Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 is an enzyme that in humans is encoded by the DHX32 gene.^[1]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates two transcript variants, but the full length nature of one of the variants has not been defined.

Further reading

• Alli Z, Chen Y, Abdul Wajid S . A role for DHX32 in regulating T-cell apoptosis. . Anticancer Res. . 27 . 1A . 373–7 . 2007 . 17352256 . etal.
• Chen Y, Alli Z, Ackerley C . Altered distribution of heat shock protein 60 (Hsp60) with dysregulated expression of DHX32. . Exp. Mol. Pathol. . 82 . 3 . 256–61 . 2007 . 17174952 . 10.1016/j.yexmp.2006.11.002 . etal.
• Alli Z, Ackerley C, Chen Y . Nuclear and mitochondrial localization of the putative RNA helicase DHX32. . Exp. Mol. Pathol. . 81 . 3 . 245–8 . 2007 . 16959245 . 10.1016/j.yexmp.2006.07.005 . etal.
• Alli Z, Nam EH, Beimnet K, Abdelhaleem M . The activation-induced expression of DHX32 in Jurkat T cells is specific and involves calcium and nuclear factor of activated T cells. . Cell. Immunol. . 237 . 2 . 141–6 . 2006 . 16414036 . 10.1016/j.cellimm.2005.12.003 .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Abdelhaleem M . The novel helicase homologue DDX32 is down-regulated in acute lymphoblastic leukemia. . Leuk. Res. . 26 . 10 . 945–54 . 2002 . 12163057 . 10.1016/S0145-2126(02)00040-1 .
• Liu J, Yuan Y, Huan J, Shen Z . Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2. . Oncogene . 20 . 3 . 336–45 . 2001 . 11313963 . 10.1038/sj.onc.1204098 . free .

Notes and References

1. Web site: Entrez Gene: DHX32 DEAH (Asp-Glu-Ala-His) box polypeptide 32.