DHX15 explained

Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 is an enzyme that in humans is encoded by the DHX15 gene.^{[1] [2]}

The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing. It may have tumor suppressor activity.^[3]

Further reading

• Lüking A, Stahl U, Schmidt U . The protein family of RNA helicases . Crit. Rev. Biochem. Mol. Biol. . 33 . 4 . 259–96 . 1998 . 9747670 . 10.1080/10409239891204233 .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Will CL, Schneider C, Hossbach M . The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome . RNA . 10 . 6 . 929–41 . 2004 . 15146077 . 10.1261/rna.7320604 . 1370585 . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Fouraux MA, Kolkman MJ, Van der Heijden A . The human La (SS-B) autoantigen interacts with DDX15/hPrp43, a putative DEAH-box RNA helicase . RNA . 8 . 11 . 1428–43 . 2002 . 12458796 . 10.1017/S1355838202021076 . 1370349 . etal.
• Ono Y, Ohno M, Shimura Y . Identification of a putative RNA helicase (HRH1), a human homolog of yeast Prp22 . Mol. Cell. Biol. . 14 . 11 . 7611–20 . 1994 . 7935475 . 10.1128/MCB.14.11.7611. 359297 .

Notes and References

1. Imamura O, Sugawara M, Furuichi Y . Cloning and characterization of a putative human RNA helicase gene of the DEAH-box protein family . Biochem Biophys Res Commun . 240 . 2 . 335–40 . Dec 1997 . 9388478 . 10.1006/bbrc.1997.7585 .
2. Web site: Entrez Gene: DHX15 DEAH (Asp-Glu-Ala-His) box polypeptide 15.
3. Ito S, Koso H, Sakamoto K . RNA helicase DHX15 acts as a tumour suppressor in glioma . Br J Cancer . 117 . 1349–1359 . Oct 2017 . 9 . 10.1038/bjc.2017.273. 28829764 . 5672939 . free .