DHRS7 explained

Dehydrogenase/reductase (SDR family) member 7 is a protein that in humans is encoded by the DHRS7 gene.^[1]

Function

Short-chain dehydrogenases/reductases (SDRs), such as DHRS7, catalyze the oxidation/reduction of a wide range of substrates, including retinoids and steroids.^{[2] [3]}

Further reading

• Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U . The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative . Chemico-Biological Interactions . 178 . 1–3 . 94–8 . March 2009 . 19027726 . 2896744 . 10.1016/j.cbi.2008.10.040 . 2009CBI...178...94P .
• Ramasamy A, Curjuric I, Coin LJ, Kumar A, McArdle WL, Imboden M, Leynaert B, Kogevinas M, Schmid-Grendelmeier P, Pekkanen J, Wjst M, Bircher AJ, Sovio U, Rochat T, Hartikainen AL, Balding DJ, Jarvelin MR, Probst-Hensch N, Strachan DP, Jarvis DL . A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order . The Journal of Allergy and Clinical Immunology . 128 . 5 . 996–1005 . November 2011 . 22036096 . 10.1016/j.jaci.2011.08.030 . free .
• Štambergová H, Škarydová L, Dunford JE, Wsól V . Biochemical properties of human dehydrogenase/reductase (SDR family) member 7 . Chemico-Biological Interactions . 207 . 52–7 . January 2014 . 1 . 24246706 . 10.1016/j.cbi.2013.11.003 . 2014CBI...207...52S .
• Skarka A, Škarydová L, Štambergová H, Wsól V . Purification and reconstitution of human membrane-bound DHRS7 (SDR34C1) from Sf9 cells . Protein Expression and Purification . 95 . 44–49 . March 2014 . 24316191 . 10.1016/j.pep.2013.11.013 .
• Seibert JK, Quagliata L, Quintavalle C, Hammond TG, Terracciano L, Odermatt A . A role for the dehydrogenase DHRS7 (SDR34C1) in prostate cancer . Cancer Medicine . 4 . 11 . 1717–1729 . November 2015 . 26311046 . 4673999 . 10.1002/cam4.517 .
• Zemanová L, Kirubakaran P, Pato IH, Štambergová H, Vondrášek J . The identification of new substrates of human DHRS7 by molecular modeling and in vitro testing . International Journal of Biological Macromolecules . 105, Part 1 . 171–182 . December 2017 . Pt 1 . 28687384 . 10.1016/j.ijbiomac.2017.07.012 .
• Stücheli S, Araya S, Ercan C, Moser SO, Gallon J, Jenö P, Piscuoglio S, Terracciano L, Odermatt A . The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples . Cancers (Basel) . 14 . 13 . June 2022 . 3074 . 35804847 . 9264982 . 10.3390/cancers14133074 . free .

Notes and References

1. Web site: Entrez Gene: Dehydrogenase/reductase (SDR family) member 7. 2014-04-28 .
2. Araya S, Kratschmar DV, Tsachaki M, Stücheli S, Beck KR, Odermatt A . DHRS7 (SDR34C1) – A new player in the regulation of androgen receptor function by inactivation of 5α-dihydrotestosterone? . The Journal of Steroid Biochemistry and Molecular Biology . 171 . 288–295 . July 2017 . 28457967 . 10.1016/j.jsbmb.2017.04.013 . 30060280 . free .
3. Štambergová H, Zemanová L, Lundová T, Malčeková B, Skarka A, Šaft M, Wsól V . Human DHRS7, promising enzyme in metabolism of steroids and retinoids? . Journal of Steroid Biochemistry and Molecular Biology . 155, Part A . 112–119 . January 2016 . Pt A . 26466768 . 10.1016/j.jsbmb.2015.09.041. 25848948 .