DHR1 domain explained

DHR1 (DOCK homology region 1), also known as CZH1 or Docker1, is a protein domain of approximately 200–250 amino acids that is present in the DOCK family of signalling proteins.^[1] This domain binds phospholipids and so may assist in recruitment to cellular membranes.^[2] There is evidence that this domain may also mediate protein–protein interactions.^[3]

Further reading

• Côté JF, Vuori K. Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity . J. Cell Sci. . 115 . Pt 24 . 4901–13. 2002 . 12432077 . 10.1242/jcs.00219 .
• Côté JF, Vuori K. GEF what? Dock180 and related proteins help Rac to polarize cells in new ways . Trends Cell Biol. . 17 . 8 . 383–93. 2007 . 17765544 . 10.1016/j.tcb.2007.05.001 . 2887429 .

Notes and References

1. Meller N, Merlot S, Guda C . CZH proteins: a new family of Rho-GEFs . J. Cell Sci. . 118 . Pt 21 . 4937–46 . November 2005 . 16254241 . 10.1242/jcs.02671. free .
2. Côté JF, Motoyama AB, Bush JA, Vuori K . A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling . Nat. Cell Biol. . 7 . 8 . 797–807 . August 2005 . 16025104 . 10.1038/ncb1280. 1352170 .
3. Hara S . The DHR1 Domain of DOCK180 Binds to SNX5 and Regulates Cation-independent Mannose 6-phosphate Receptor Transport . Mol. Biol. Cell . 19 . 9. 3823–35. July 2008 . 18596235 . 10.1091/mbc.E08-03-0314. 2526700 . vanc . Kiyokawa E . Iemura SI . 3 . Natsume . T. . Wassmer . T. . Cullen . P. J. . Hiai . H. . Matsuda . M. .