DEK (gene) explained

The human DEK gene encodes the DEK protein.^{[1] [2]}

Function

This gene encodes a protein with one SAP domain. The protein binds to cruciform DNA and DNA coiled into a superhelix, thereby inducing positive supercoils into closed circular DNA. It is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region increased expression of this gene and the presence of antibodies against this protein are all associated with various diseases.

Interactions

DEK interacts with TFAP2A.^[3]

Further reading

• von Lindern M, Fornerod M, Soekarman N, van Baal S, Jaegle M, Hagemeijer A, Bootsma D, Grosveld G . Translocation t(6;9) in acute non-lymphocytic leukaemia results in the formation of a DEK-CAN fusion gene . Baillière's Clinical Haematology . 5 . 4 . 857–79 . 1992 . 1308167 . 10.1016/s0950-3536(11)80049-1 .
• Waldmann T, Scholten I, Kappes F, Hu HG, Knippers R . The DEK protein--an abundant and ubiquitous constituent of mammalian chromatin . Gene . 343 . 1 . 1–9 . 2004 . 15563827 . 10.1016/j.gene.2004.08.029 .
• Denisenko ON, O'Neill B, Ostrowski J, Van Seuningen I, Bomsztyk K . Zik1, a transcriptional repressor that interacts with the heterogeneous nuclear ribonucleoprotein particle K protein . J. Biol. Chem. . 271 . 44 . 27701–6 . 1996 . 8910362 . 10.1074/jbc.271.44.27701 . free .
• Fu GK, Grosveld G, Markovitz DM . DEK, an autoantigen involved in a chromosomal translocation in acute myelogenous leukemia, binds to the HIV-2 enhancer . Proc. Natl. Acad. Sci. U.S.A. . 94 . 5 . 1811–5 . 1997 . 9050861 . 19999 . 10.1073/pnas.94.5.1811 . 1997PNAS...94.1811F . free .
• Murray KJ, Szer W, Grom AA, Donnelly P, Levinson JE, Giannini EH, Glass DN, Szer IS . Antibodies to the 45 kDa DEK nuclear antigen in pauciarticular onset juvenile rheumatoid arthritis and iridocyclitis: selective association with MHC gene . J. Rheumatol. . 24 . 3 . 560–7 . 1997 . 9058666 .
• Forero L, Zwirner NW, Fink CW, Fernández-Viña MA, Stastny P . Juvenile arthritis, HLA-A2 and binding of DEK oncogene-peptides . Hum. Immunol. . 59 . 7 . 443–50 . 1998 . 9684994 . 10.1016/S0198-8859(98)00034-2 .
• Dong X, Michelis MA, Wang J, Bose R, DeLange T, Reeves WH . Autoantibodies to DEK oncoprotein in a patient with systemic lupus erythematosus and sarcoidosis . Arthritis Rheum. . 41 . 8 . 1505–10 . 1998 . 9704652 . 10.1002/1529-0131(199808)41:8<1505::AID-ART23>3.0.CO;2-N .
• Wichmann I, Garcia-Lozano JR, Respaldiza N, Gonzalez-Escribano MF, Nuñez-Roldan A . Autoantibodies to transcriptional regulation proteins DEK and ALY in a patient with systemic lupus erythematosus . Hum. Immunol. . 60 . 1 . 57–62 . 1999 . 9952027 . 10.1016/S0198-8859(98)00085-8 .
• Alexiadis V, Waldmann T, Andersen J, Mann M, Knippers R, Gruss C . The protein encoded by the proto-oncogene DEK changes the topology of chromatin and reduces the efficiency of DNA replication in a chromatin-specific manner . Genes Dev. . 14 . 11 . 1308–12 . 2000 . 10.1101/gad.14.11.1308 . 10837023 . 316669 .
• McGarvey T, Rosonina E, McCracken S, Li Q, Arnaout R, Mientjes E, Nickerson JA, Awrey D, Greenblatt J, Grosveld G, Blencowe BJ . The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes . J. Cell Biol. . 150 . 2 . 309–20 . 2000 . 10908574 . 2180225 . 10.1083/jcb.150.2.309 .
• Grottke C, Mantwill K, Dietel M, Schadendorf D, Lage H . Identification of differentially expressed genes in human melanoma cells with acquired resistance to various antineoplastic drugs . Int. J. Cancer . 88 . 4 . 535–46 . 2000 . 11058868 . 10.1002/1097-0215(20001115)88:4<535::AID-IJC4>3.0.CO;2-V . 24030621 .
• Le Hir H, Izaurralde E, Maquat LE, Moore MJ . The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions . EMBO J. . 19 . 24 . 6860–9 . 2000 . 11118221 . 305905 . 10.1093/emboj/19.24.6860 .
• Kappes F, Burger K, Baack M, Fackelmayer FO, Gruss C . Subcellular localization of the human proto-oncogene protein DEK . J. Biol. Chem. . 276 . 28 . 26317–23 . 2001 . 11333257 . 10.1074/jbc.M100162200 . free .
• Waldmann T, Eckerich C, Baack M, Gruss C . The ubiquitous chromatin protein DEK alters the structure of DNA by introducing positive supercoils . J. Biol. Chem. . 277 . 28 . 24988–94 . 2002 . 11997399 . 10.1074/jbc.M204045200 . free .
• Larramendy ML, Niini T, Elonen E, Nagy B, Ollila J, Vihinen M, Knuutila S . Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis . Haematologica . 87 . 6 . 569–77 . 2002 . 12031912 .
• Hollenbach AD, McPherson CJ, Mientjes EJ, Iyengar R, Grosveld G . Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek . J. Cell Sci. . 115 . Pt 16 . 3319–30 . 2002 . 10.1242/jcs.115.16.3319 . 12140263 .
• Krithivas A, Fujimuro M, Weidner M, Young DB, Hayward SD . Protein interactions targeting the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomes . J. Virol. . 76 . 22 . 11596–604 . 2002 . 12388720 . 136775 . 10.1128/JVI.76.22.11596-11604.2002 .

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein DEK

Notes and References

1. von Lindern M, Fornerod M, van Baal S, Jaegle M, de Wit T, Buijs A, Grosveld G . The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA . Mol. Cell. Biol. . 12 . 4 . 1687–97 . Apr 1992 . 1549122 . 369612 . 10.1128/mcb.12.4.1687.
2. Web site: Entrez Gene: DEK DEK oncogene (DNA binding).
3. Campillos M, García MA, Valdivieso F, Vázquez J . Transcriptional activation by AP-2alpha is modulated by the oncogene DEK . Nucleic Acids Res. . 31 . 5 . 1571–5 . Mar 2003 . 12595566 . 149840 . 10.1093/nar/gkg247 .