DEGS2 explained

Delta(4)-desaturase, sphingolipid 2 is a protein that in humans is encoded by the DEGS2 gene.^[1]

Function

This gene encodes a bifunctional enzyme that is involved in the biosynthesis of sphingolipids in human skin and in other phytosphingolipid-containing tissues. This enzyme can act as a sphingolipid delta(4)-desaturase, and also as a sphingolipid C4-hydroxylase.

Further reading

• Devlin CM, Lahm T, Hubbard WC, Van Demark M, Wang KC, Wu X, Bielawska A, Obeid LM, Ivan M, Petrache I . Dihydroceramide-based response to hypoxia . The Journal of Biological Chemistry . 286 . 44 . 38069–38078 . Nov 2011 . 21914808 . 3207482 . 10.1074/jbc.M111.297994 . free .
• Aouizerat BE, Vittinghoff E, Musone SL, Pawlikowska L, Kwok PY, Olgin JE, Tseng ZH . GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease . BMC Cardiovascular Disorders . 11 . 29 . 2011 . 21658281 . 3141757 . 10.1186/1471-2261-11-29 . free .
• Mizutani Y, Kihara A, Igarashi Y . Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation . FEBS Letters . 563 . 1–3 . 93–97 . Apr 2004 . 15063729 . 10.1016/S0014-5793(04)00274-1 . 12638946 .

Notes and References

1. Web site: Entrez Gene: Delta(4)-desaturase, sphingolipid 2 .