DEFB129 explained

Beta-defensin 129 is a protein that in humans is encoded by the DEFB129 gene.^{[1] [2]}

Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13.

Further reading

• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Clark HF . The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 . vanc. Gurney AL . Abaya E . 3 . Baker . K . Baldwin . D . Brush . J . Chen . J . Chow . B . Chui . C .
• Rodríguez-Jiménez FJ . Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis . Genomics . 81 . 2 . 175–83 . 2003 . 12620395 . 10.1016/S0888-7543(02)00034-4 . vanc. Krause A . Schulz S . 3 . Forssmann . Wolf-Georg . Conejo-Garcia . José-Ramón . Schreeb . Rainer . Motzkus . Dirk .
• Kao CY, Chen Y, Zhao YH, Wu R . ORFeome-based search of airway epithelial cell-specific novel human [beta]-defensin genes . Am. J. Respir. Cell Mol. Biol. . 29 . 1 . 71–80 . 2003 . 12600824 . 10.1165/rcmb.2002-0205OC . 10.1.1.108.7808 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Deloukas P . The DNA sequence and comparative analysis of human chromosome 20 . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . vanc. Matthews LH . Ashurst J . 3 . Burton . J. . Gilbert . J. G. R. . Jones . M. . Stavrides . G. . Almeida . J. P. . Babbage . A. K. . 2001Natur.414..865D . free .

Notes and References

1. Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, ((McCray PB Jr)) . Discovery of five conserved β-defensin gene clusters using a computational search strategy . Proc Natl Acad Sci U S A . 99 . 4 . 2129–33 . Feb 2002 . 11854508 . 122330 . 10.1073/pnas.042692699 . 2002PNAS...99.2129S . free .
2. Web site: Entrez Gene: DEFB129 defensin, beta 129.