DEFB127 explained

Beta-defensin 127 is a protein that in humans is encoded by the DEFB127 gene.^{[1] [2]}

Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13.

Further reading

• van Wetering S, Sterk PJ, Rabe KF, Hiemstra PS . Defensins: key players or bystanders in infection, injury, and repair in the lung? . J. Allergy Clin. Immunol. . 104 . 6 . 1131–8 . 2000 . 10588992 . 10.1016/S0091-6749(99)70004-7 . free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Zhang Z, Henzel WJ . Signal peptide prediction based on analysis of experimentally verified cleavage sites. . Protein Sci. . 13 . 10 . 2819–24 . 2005 . 15340161 . 10.1110/ps.04682504 . 2286551 .
• Clark HF, Gurney AL, Abaya E . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 . etal.
• Rodríguez-Jiménez FJ, Krause A, Schulz S . Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis. . Genomics . 81 . 2 . 175–83 . 2003 . 12620395 . 10.1016/S0888-7543(02)00034-4 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Deloukas P, Matthews LH, Ashurst J . The DNA sequence and comparative analysis of human chromosome 20. . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . 2001Natur.414..865D . etal. free .

Notes and References

1. Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, ((McCray PB Jr)) . Discovery of five conserved beta -defensin gene clusters using a computational search strategy . Proc Natl Acad Sci U S A . 99 . 4 . 2129–33 . Feb 2002 . 11854508 . 122330 . 10.1073/pnas.042692699 . 2002PNAS...99.2129S . free .
2. Web site: Entrez Gene: DEFB127 defensin, beta 127.