DEC1 explained

Deleted in esophageal cancer 1 is a protein that in humans is encoded by the DEC1 gene.^{[1] [2] [3]}

Function

The function of this gene is not known. This gene is located in a region commonly deleted in esophageal squamous cell carcinomas. Gene expression is reduced or absent in these carcinomas, associated with lymph node metastasis, and thus this is a candidate tumor suppressor gene for esophageal squamous cell carcinomas.

Further reading

• Qian Y, Zhang J, Yan B, Chen X . DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence. . J. Biol. Chem. . 283 . 5 . 2896–905 . 2008 . 18025081 . 10.1074/jbc.M708624200 . 4118587 . free .
• Leung AC, Wong VC, Yang LC, Chan PL, Daigo Y, Nakamura Y, Qi RZ, Miller LD, Liu ET, Wang LD, Li JL, Law S, Tsao SW, Lung ML . Frequent decreased expression of candidate tumor suppressor gene, DEC1, and its anchorage-independent growth properties and impact on global gene expression in esophageal carcinoma. . Int. J. Cancer . 122 . 3 . 587–94 . 2008 . 17943723 . 10.1002/ijc.23144 . 28437103 .
• Li Y, Xie M, Yang J, Yang D, Deng R, Wan Y, Yan B . The expression of antiapoptotic protein survivin is transcriptionally upregulated by DEC1 primarily through multiple sp1 binding sites in the proximal promoter. . Oncogene . 25 . 23 . 3296–306 . 2006 . 16462771 . 10.1038/sj.onc.1209363 . 4114758 .
• Preusser M, Birner P, Ambros IM, Ambros PF, Budka H, Harris AL, Hainfellner JA . DEC1 expression in 1p-aberrant oligodendroglial neoplasms. . Histol. Histopathol. . 20 . 4 . 1173–7 . 2006 . 16136500 .
• Yang L, Leung AC, Ko JM, Lo PH, Tang JC, Srivastava G, Oshimura M, Stanbridge EJ, Daigo Y, Nakamura Y, Tang CM, Lau KW, Law S, Lung ML . Tumor suppressive role of a 2.4 Mb 9q33-q34 critical region and DEC1 in esophageal squamous cell carcinoma. . Oncogene . 24 . 4 . 697–705 . 2005 . 15580306 . 10.1038/sj.onc.1208179 . free .
• Wong VC, Ko JM, Qi RZ, Li PJ, Wang LD, Li JL, Chan YP, Chan KW, Stanbridge EJ, Lung ML . Abrogated expression of DEC1 during oesophageal squamous cell carcinoma progression is age- and family history-related and significantly associated with lymph node metastasis. . British Journal of Cancer . 104 . 5 . 841–9 . Mar 1, 2011 . 21326238 . 10.1038/bjc.2011.25 . 3048215.
• Leung AC, Wong VC, Yang LC, Chan PL, Daigo Y, Nakamura Y, Qi RZ, Miller LD, Liu ET, Wang LD, Li JL, Law S, Tsao SW, Lung ML . Frequent decreased expression of candidate tumor suppressor gene, DEC1, and its anchorage-independent growth properties and impact on global gene expression in esophageal carcinoma. . International Journal of Cancer . 122 . 3 . 587–94 . Feb 1, 2008 . 17943723 . 10.1002/ijc.23144 . 28437103 .

Notes and References

1. Miura K, Suzuki K, Tokino T, Isomura M, Inazawa J, Matsuno S, Nakamura Y . Detailed deletion mapping in squamous cell carcinomas of the esophagus narrows a region containing a putative tumor suppressor gene to about 200 kilobases on distal chromosome 9q . Cancer Res . 56 . 7 . 1629–34 . May 1996 . 8603412 .
2. Nishiwaki T, Daigo Y, Kawasoe T, Nakamura Y . Isolation and mutational analysis of a novel human cDNA, DEC1 (deleted in esophageal cancer 1), derived from the tumor suppressor locus in 9q32 . Genes Chromosomes Cancer . 27 . 2 . 169–76 . Feb 2000 . 10612805 . 10.1002/(SICI)1098-2264(200002)27:2<169::AID-GCC8>3.0.CO;2-M . 25576076 .
3. Web site: Entrez Gene: DEC1 deleted in esophageal cancer 1.