DDX6 explained

Probable ATP-dependent RNA helicase DDX6 is an enzyme that in humans is encoded by the DDX6 gene.^{[1] [2]}

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein. It may contribute to the cell proliferation and carcinogenesis.

Further reading

• Akao Y, Seto M, Yamamoto K . The RCK gene associated with t(11;14) translocation is distinct from the MLL/ALL-1 gene with t(4;11) and t(11;19) translocations . Cancer Res. . 52 . 21 . 6083–7 . 1992 . 1394235 . etal.
• Akao Y, Marukawa O, Morikawa H . The rck/p54 candidate proto-oncogene product is a 54-kilodalton D-E-A-D box protein differentially expressed in human and mouse tissues . Cancer Res. . 55 . 15 . 3444–9 . 1995 . 7614484 . etal.
• Zhang WJ, Wu JY . Functional properties of p54, a novel SR protein active in constitutive and alternative splicing . Mol. Cell. Biol. . 16 . 10 . 5400–8 . 1996 . 8816452 . 10.1128/MCB.16.10.5400. 231539 .
• Akiyama K, Akao Y, Yokoyama M . Expression of two dead box genes (DDX1 and DDX6) is independent of that of MYCN in human neuroblastoma cell lines . Biochem. Mol. Biol. Int. . 47 . 4 . 563–8 . 1999 . 10319407 . 10.1080/15216549900201603. 45609314 . etal. free .
• Nakagawa Y, Morikawa H, Hirata I . Overexpression of rck/p54, a DEAD box protein, in human colorectal tumours . Br. J. Cancer . 80 . 5–6 . 914–7 . 1999 . 10360675 . 10.1038/sj.bjc.6690441 . 2362290 . etal.
• Smillie DA, Sommerville J . RNA helicase p54 (DDX6) is a shuttling protein involved in nuclear assembly of stored mRNP particles . J. Cell Sci. . 115 . Pt 2 . 395–407 . 2002 . 10.1242/jcs.115.2.395 . 11839790 .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Miyaji K, Nakagawa Y, Matsumoto K . Overexpression of a DEAD box/RNA helicase protein, rck/p54, in human hepatocytes from patients with hepatitis C virus-related chronic hepatitis and its implication in hepatocellular carcinogenesis . J. Viral Hepat. . 10 . 4 . 241–8 . 2003 . 12823589 . 10.1046/j.1365-2893.2003.00447.x . 36830183 . etal.
• Matsui T, Hogetsu K, Akao Y . Crystallization and X-ray analysis of the N-terminal core domain of a tumour-associated human DEAD-box RNA helicase, rck/p54 . Acta Crystallogr. D . 60 . Pt 1 . 156–9 . 2004 . 14684915 . 10.1107/S0907444903024223 . 2004AcCrD..60..156M . etal.
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J . Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping . Mol. Cell . 20 . 6 . 905–15 . 2006 . 16364915 . 10.1016/j.molcel.2005.10.031 . free .
• Matsui T, Hogetsu K, Usukura J . Structural insight of human DEAD-box protein rck/p54 into its substrate recognition with conformational changes . Genes Cells . 11 . 4 . 439–52 . 2006 . 16611246 . 10.1111/j.1365-2443.2006.00951.x . 29643976 . etal. free .
• Wichroski MJ, Robb GB, Rana TM . Human Retroviral Host Restriction Factors APOBEC3G and APOBEC3F Localize to mRNA Processing Bodies . PLOS Pathog. . 2 . 5 . e41 . 2006 . 16699599 . 10.1371/journal.ppat.0020041 . 1458959 . free .
• Chu CY, Rana TM . Translation Repression in Human Cells by MicroRNA-Induced Gene Silencing Requires RCK/p54 . PLOS Biol. . 4 . 7 . e210 . 2006 . 16756390 . 10.1371/journal.pbio.0040210 . 1475773 . free .
• Ewing RM, Chu P, Elisma F . Large-scale mapping of human protein–protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . etal.
• Nonhoff U, Ralser M, Welzel F . Ataxin-2 Interacts with the DEAD/H-Box RNA Helicase DDX6 and Interferes with P-Bodies and Stress Granules . Mol. Biol. Cell . 18 . 4 . 1385–96 . 2007 . 17392519 . 10.1091/mbc.E06-12-1120 . 1838996 . etal.

Notes and References

1. Lu D, Yunis JJ . Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3 . Nucleic Acids Res . 20 . 8 . 1967–72 . Jun 1992 . 1579499 . 312313 . 10.1093/nar/20.8.1967 .
2. Web site: Entrez Gene: DDX6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6.