DDX53 explained

DEAD-box helicase 53 is a protein that in humans is encoded by the DDX53 gene.^[1]

Function

This intronless gene encodes a protein which contains several domains found in members of the DEAD-box helicase protein family. Other members of this protein family participate in ATP-dependent RNA unwinding.

Further reading

• Cho B, Lim Y, Lee DY, Park SY, Lee H, Kim WH, Yang H, Bang YJ, Jeoung DI . Identification and characterization of a novel cancer/testis antigen gene CAGE . Biochem. Biophys. Res. Commun. . 292 . 3 . 715–26 . 2002 . 11922625 . 10.1006/bbrc.2002.6701 .
• Cho B, Lee H, Jeong S, Bang YJ, Lee HJ, Hwang KS, Kim HY, Lee YS, Kang GH, Jeoung DI . Promoter hypomethylation of a novel cancer/testis antigen gene CAGE is correlated with its aberrant expression and is seen in premalignant stage of gastric carcinoma . Biochem. Biophys. Res. Commun. . 307 . 1 . 52–63 . 2003 . 12849980 . 10.1016/s0006-291x(03)01121-5.
• Shim H, Lee H, Jeoung D . Cancer/testis antigen cancer-associated gene (CAGE) promotes motility of cancer cells through activation of focal adhesion kinase (FAK) . Biotechnol. Lett. . 28 . 24 . 2057–63 . 2006 . 17028776 . 10.1007/s10529-006-9190-8 . 7168043 .
• Lee TS, Kim JW, Kang GH, Park NH, Song YS, Kang SB, Lee HP . DNA hypomethylation of CAGE promotors in squamous cell carcinoma of uterine cervix . Ann. N. Y. Acad. Sci. . 1091 . 218–24 . 2006 . 1 . 17341616 . 10.1196/annals.1378.068 . 2006NYASA1091..218L . 28013856 .
• Kim Y, Jeoung D . Role of CAGE, a novel cancer/testis antigen, in various cellular processes, including tumorigenesis, cytolytic T lymphocyte induction, and cell motility . J. Microbiol. Biotechnol. . 18 . 3 . 600–10 . 2008 . 18388483 .
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• Kim Y, Park H, Park D, Lee YS, Choe J, Hahn JH, Lee H, Kim YM, Jeoung D . Cancer/testis antigen CAGE exerts negative regulation on p53 expression through HDAC2 and confers resistance to anti-cancer drugs . J. Biol. Chem. . 285 . 34 . 25957–68 . 2010 . 20534591 . 2923988 . 10.1074/jbc.M109.095950 . free .
• Kim Y, Kim H, Park D, Han M, Lee H, Lee YS, Choe J, Kim YM, Jeoung D . miR-217 and CAGE form feedback loop and regulates the response to anti-cancer drugs through EGFR and HER2 . Oncotarget . 7 . 9 . 10297–321 . 2016 . 26863629 . 4891121 . 10.18632/oncotarget.7185 .
• Kim H, Kim Y, Goh H, Jeoung D . Histone Deacetylase-3/CAGE Axis Targets EGFR Signaling and Regulates the Response to Anti-Cancer Drugs . Mol. Cells . 39 . 3 . 229–41 . 2016 . 26883907 . 4794605 . 10.14348/molcells.2016.2244 .

Notes and References

1. Web site: Entrez Gene: DEAD-box helicase 53. 2017-08-18.