DDX42 explained

ATP-dependent RNA helicase DDX42 is an enzyme that in humans is encoded by the DDX42 gene.^[1]

Function

This gene encodes a member of the Asp-Glu-Ala-Asp (DEAD) box protein family. Members of this protein family are putative RNA helicases, and are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Two transcript variants encoding the same protein have been identified for this gene.^[2]

Interactions

DDX42 has been shown to interact with SF3B1.^[3]

Further reading

• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . Nov 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Uhlmann-Schiffler H, Jalal C, Stahl H . Ddx42p--a human DEAD box protein with RNA chaperone activities . Nucleic Acids Research . 34 . 1 . 10–22 . 2006 . 16397294 . 1325199 . 10.1093/nar/gkj403 .
• Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP . Phosphoproteomic analysis of the developing mouse brain . Molecular & Cellular Proteomics . 3 . 11 . 1093–101 . Nov 2004 . 15345747 . 10.1074/mcp.M400085-MCP200 . free .
• Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R . Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein . The EMBO Journal . 21 . 18 . 4978–88 . Sep 2002 . 12234937 . 126279 . 10.1093/emboj/cdf480 .

Notes and References

1. Suk K, Kim S, Kim YH, Oh SH, Lee MK, Kim KW, Kim HD, Seo YS . Identification of a novel human member of the DEAD box protein family . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease . 1501 . 1 . 63–9 . Apr 2000 . 10727850 . 10.1016/S0925-4439(00)00010-7 .
2. Web site: Entrez Gene: DDX42 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42.
3. Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R . Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein . The EMBO Journal . 21 . 18 . 4978–88 . Sep 2002 . 12234937 . 126279 . 10.1093/emboj/cdf480 .